tert-butyl 4-[(2-fluorophenyl)(1-hydroxycyclobutyl)acetyl]piperazine-1-carboxylate | 850466-47-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: tert-butyl 4-[(2-fluorophenyl)(1-hydroxycyclobutyl)acetyl]piperazine-1-carboxylate
• 英文别名: Tert-butyl 4-[2-(2-fluorophenyl)-2-(1-hydroxycyclobutyl)acetyl]piperazine-1-carboxylate
• CAS: 850466-47-6
• 化学式: C₂₁H₂₉FN₂O₄
• 分子量: 392.471
• InChiKey: GDIGYFOPZUJHPA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  70.1
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] PHENYLPIPERAZINE CYCLOALKANOL DERIVATIVES AND METHODS OF THEIR USE<br/>[FR] DERIVES DE PHENYLPIPERAZINE CYCLOALCANOL ET METHODES D'UTILISATION ASSOCIEES
  申请人：WYETH CORP

  公开号：WO2005037808A1

  公开（公告）日：2005-04-28

  The present invention is directed to phenylpiperazine cycloalkanol derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibrornyalgia, pain, diabetic neuropathy, and combinations thereof.

  本发明涉及苯基哌嗪环丙醇衍生物，含有这些衍生物的组合物，以及它们用于预防和治疗由单胺再摄取改善的病症的方法，包括但不限于血管运动症状（VMS）、性功能障碍、胃肠道和泌尿系统疾病、慢性疲劳综合征、纤维肌痛综合征、神经系统疾病等，以及从主要抑郁症、血管运动症状、压力性和切勿性尿失禁、纤维肌痛、疼痛、糖尿病神经病变等病症组合中选择的特定病症的组合。
• Phenylpiperazine cycloalkanol derivatives and methods of their use
  申请人：Mahaney Erin Paige

  公开号：US20050143394A1

  公开（公告）日：2005-06-30

  The present invention is directed to phenylpiperazine cycloalkanol derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.

  本发明涉及苯基哌嗪环烷醇衍生物、含有这些衍生物的组合物以及它们的使用方法，用于预防和治疗由单胺再摄取改善的症状，包括但不限于血管运动症状（VMS）、性功能障碍、胃肠和泌尿系统疾病、慢性疲劳综合征、纤维肌痛综合征、神经系统疾病和其组合，尤其是从包括重度抑郁障碍、血管运动症状、压力和急迫性尿失禁、纤维肌痛、疼痛、糖尿病神经病变和其组合的组中选择的那些症状。
• PHENYLPIPERAZINE CYCLOALKANOL DERIVATIVES AND METHODS OF THEIR USE
  申请人：Wyeth

  公开号：EP1673358A1

  公开（公告）日：2006-06-28
• US7531543B2
  申请人：——

  公开号：US7531543B2

  公开（公告）日：2009-05-12