1-(pyridin-3-yl)-3-(4-(4-(trifluoromethyl)phenyl)chroman-4-yl)urea | 1561765-49-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 1-(pyridin-3-yl)-3-(4-(4-(trifluoromethyl)phenyl)chroman-4-yl)urea
• 英文别名: 1-Pyridin-3-yl-3-[4-[4-(trifluoromethyl)phenyl]-2,3-dihydrochromen-4-yl]urea
• CAS: 1561765-49-8
• 化学式: C₂₂H₁₈F₃N₃O₂
• 分子量: 413.399
• InChiKey: SNXJVBZZSMUECY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  30
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  63.2
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• [EN] PYRAZOLYL-UREAS AS KINASE INHIBITORS<br/>[FR] PYRAZOLYL-URÉES UTILISÉES COMME INHIBITEURS DE KINASE
  申请人：RESPIVERT LTD

  公开号：WO2014027209A1

  公开（公告）日：2014-02-20

  There are provided compounds of formula I, wherein R, R1, Ra, Rb, Q, X and Y have meanings given in the description, which compounds have antiinflammatory activity (e.g. through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.

  提供了具有式I的化合物，其中R、R1、Ra、Rb、Q、X和Y的含义如描述中所给，这些化合物具有抗炎活性（例如通过抑制p38丝裂原激活蛋白激酶家族中的一个或多个成员；Syk激酶；以及酪氨酸激酶Src家族的成员之一），并且在治疗中发挥作用，包括在制药组合中，特别是在治疗炎症性疾病方面，包括肺部、眼睛和肠道的炎症性疾病。
• CHROMAN DERIVATIVES AS TRPM8 INHIBITORS
  申请人：AMGEN INC.

  公开号：US20140045855A1

  公开（公告）日：2014-02-13

  Chroman compounds and derivatives of Formula I are useful inhibitors of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.

  Formula I的Chroman化合物和衍生物是TRPM8的有用抑制剂。这些化合物在治疗多种由TRPM8介导的疾病和症状方面具有用途，并可用于制备治疗这些疾病和症状的药物和药物组合物。这些疾病的例子包括，但不限于，偏头痛和神经病性疼痛。Formula I的化合物具有以下结构：变量的定义在此提供。
• PYRAZOLYL-UREAS AS KINASE INHIBITORS
  申请人：Respivert Limited

  公开号：EP2885284A1

  公开（公告）日：2015-06-24
• US8952009B2
  申请人：——

  公开号：US8952009B2

  公开（公告）日：2015-02-10
• [EN] CHROMAN DERIVATIVES AS TRPM8 INHIBITORS<br/>[FR] DÉRIVÉS DE CHROMANE EN TANT QU'INHIBITEURS DE TRPM8
  申请人：AMGEN INC

  公开号：WO2014025651A1

  公开（公告）日：2014-02-13

  Chroman compounds and derivatives of Formula (I) are useful inhibitors of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula (I) have the following structure: (I) where the definitions of the variables are provided herein.