[2-(11-hydroxy-4-methyl-10,11-dihydro-dibenzo[b,f]oxepin-10-yl)-ethyl]-methyl-carbamic acid tert-butyl ester | 1184947-32-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: [2-(11-hydroxy-4-methyl-10,11-dihydro-dibenzo[b,f]oxepin-10-yl)-ethyl]-methyl-carbamic acid tert-butyl ester
• 英文别名: tert-butyl N-[2-(5-hydroxy-1-methyl-5,6-dihydrobenzo[b][1]benzoxepin-6-yl)ethyl]-N-methylcarbamate
• CAS: 1184947-32-7
• 化学式: C₂₃H₂₉NO₄
• 分子量: 383.488
• InChiKey: ZRRODDZEVACBQQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  59
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] BELOXEPIN, ITS ENANTIOMERS, AND ANALOGS THEREOF FOR THE TREATMENT OF PAIN<br/>[FR] BÉLOXÉPINE, SES ÉNANTIOMÈRES ET CERTAINS DE LEURS ANALOGUES CONVENANT AU TRAITEMENT DE LA DOULEUR
  申请人：ADOLOR CORP

  公开号：WO2009105507A2

  公开（公告）日：2009-08-27

  This present disclosure provides methods of treating pain with beloxepin, beloxepin enantiomers, and analogs thereof.

  本公开披露提供了使用贝洛西平、贝洛西平对映体及其类似物治疗疼痛的方法。
• (+)-BELOXEPIN AND METHODS FOR ITS SYNTHESIS AND USE
  申请人：Le Bourdonnec Bertrand

  公开号：US20090233958A1

  公开（公告）日：2009-09-17

  This present disclosure provides compositions comprising (+)-beloxepin, methods for their synthesis and methods for their use.
• BELOXEPIN AND ANALOGS FOR THE TREATMENT OF PAIN
  申请人：Le Bourdonnec Bertrand

  公开号：US20090233959A1

  公开（公告）日：2009-09-17

  This present disclosure provides methods of treating pain with beloxepin and/or beloxepin analogs.
• (-)-BELOXEPIN AND METHODS FOR ITS SYNTHESIS AND USE
  申请人：Le Bourdonnec Bertrand

  公开号：US20090233957A1

  公开（公告）日：2009-09-17

  This present disclosure provides compositions comprising (−)-beloxepin, methods for their synthesis and methods for their use.
• US7829576B2
  申请人：——

  公开号：US7829576B2

  公开（公告）日：2010-11-09