tert-butyl [7-methoxy-3-(2-{[3-(trifluoromethyl)benzyl]amino}pyrimidin-4-yl)-1-naphthyl]carbamate | 1313486-80-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: tert-butyl [7-methoxy-3-(2-{[3-(trifluoromethyl)benzyl]amino}pyrimidin-4-yl)-1-naphthyl]carbamate
• 英文别名: tert-butyl N-[7-methoxy-3-[2-[[3-(trifluoromethyl)phenyl]methylamino]pyrimidin-4-yl]naphthalen-1-yl]carbamate
• CAS: 1313486-80-4
• 化学式: C₂₈H₂₇F₃N₄O₃
• 分子量: 524.543
• InChiKey: WACOOGRUAYJJTE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  38
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  85.4
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• Substituted Naphthalenyl-Pyrimidine Compounds
  申请人：Ashwell Mark A.

  公开号：US20110166137A1

  公开（公告）日：2011-07-07

  The present invention relates to substituted naphthalenyl-pyrimidine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted naphthalenyl-pyrimidine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

  本发明涉及取代萘基嘧啶化合物及合成这些化合物的方法。本发明还涉及含有取代萘基嘧啶化合物的药物组合物，以及通过向需要的受试者投与这些化合物和药物组合物来治疗细胞增殖紊乱疾病，如癌症的方法。
• US8173808B2
  申请人：——

  公开号：US8173808B2

  公开（公告）日：2012-05-08
• [EN] SUBSTITUTED NAPHTHALENYL-PYRIMIDINE COMPOUNDS<br/>[FR] COMPOSÉS NAPHTHALÉNYL-PYRIMIDINE SUBSTITUÉS
  申请人：ARQULE INC

  公开号：WO2011082268A2

  公开（公告）日：2011-07-07

  The present invention relates to substituted naphthalenyl-pyrimidine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted naphthalenyl-pyrimidine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.