4-环丙基-1-哌嗪丙胺 | 373608-43-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 中文名称: 4-环丙基-1-哌嗪丙胺
• 中文别名: 乙胺,2-[(4,8-二甲基-2-喹啉基)氧代]-
• 英文名称: 4-Cyclopropyl-1-piperazinepropanamine
• 英文别名: 3-(4-Cyclopropylpiperazin-1-YL)propan-1-amine
• CAS: 373608-43-6
• 化学式: C₁₀H₂₁N₃
• 分子量: 183.297
• InChiKey: CBQBKJNRELCIHZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Alkylamine derivatives of dihydropyridine NPY antagonists
  申请人：——

  公开号：US20020019384A1

  公开（公告）日：2002-02-14

  A series of non-peptidergic antagonists of NPY have been synthesized and are comprises of amino and piperazine derivatives of 4-phenyl-1,4-dihydropyridines of Formula 1. 1 where X is CH or N As antagonists of NPY-induced behavior, these compounds are expected to act as effective anorexiant agents in promoting weight loss and treating eating disorders.

  一系列非肽类的NPY拮抗剂已经被合成，包括公式1.1中的4-苯基-1,4-二氢吡啶的氨基和哌嗪衍生物，其中X为CH或N。作为NPY诱导行为的拮抗剂，这些化合物被期望作为有效的抑制食欲剂，在促进减肥和治疗进食障碍方面发挥作用。
• US6479482B2
  申请人：——

  公开号：US6479482B2

  公开（公告）日：2002-11-12
• [EN] ALKYLAMINE DERIVATIVES OF DIHYDROPYRIDINE NPY ANTAGONISTS<br/>[FR] DERIVES D'ALKYLAMINE D'ANTAGONISTES DE DIHYDROPYRIDINE NPY
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2001085173A1

  公开（公告）日：2001-11-15

  A series of non-peptidergic antagonists of NPY have been synthesized and are comprises of amino and piperazine derivatives of 4-phenyl-1,4-dihydropyridines of Formula (1) where X is CH or N. As antagonists of NPY-induced behavior, these compounds are expected to act as effective anorexiant agents in promoting weight loss and treating eating disorders.