4-[(E)-(5,6-Dihydro-5,5-dimethyl-8-phenylethynyl-2-naphthalenyl)ethynyl]benzoic acid | 215030-92-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-[(E)-(5,6-Dihydro-5,5-dimethyl-8-phenylethynyl-2-naphthalenyl)ethynyl]benzoic acid
• 英文别名: 4-[2-[5,5-dimethyl-8-(2-phenylethynyl)-6H-naphthalen-2-yl]ethynyl]benzoic acid
• CAS: 215030-92-5
• 化学式: C₂₉H₂₂O₂
• 分子量: 402.492
• InChiKey: JQBFRODVECTPMA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Retinoid antagonists and uses thereof
  申请人：——

  公开号：US20010003780A1

  公开（公告）日：2001-06-14

  Retinoid antagonist compounds have been found to be useful in the prevention and/or minimization of surgical adhesion formation. Also provided by the invention are certain novel substituted (5,6)-dihydronaphthalenyl compounds which are retinoid antagonists and possess the above-mentioned property in addition to their use as antiinflammatory agents for chronic skin inflammatory diseases, as agents for the treatment of rheumatic diseases and as agents for the treatment of various tumors as well as non-malignant proliferative skin conditions.

  发现拮抗视黄醇的化合物在预防和/或最小化手术粘连形成方面是有用的。本发明还提供了某些新型取代的（5,6）-二氢萘基化合物，它们是视黄醇拮抗剂，并具有上述特性，除了作为慢性皮肤炎症疾病的抗炎剂外，还用作治疗风湿性疾病的药物和用于治疗各种肿瘤以及非恶性增生性皮肤病的药物。
• US6319948B2
  申请人：——

  公开号：US6319948B2

  公开（公告）日：2001-11-20