(2S)-2-(tert-butoxy)-2-(7-(8-fluoro-5-methylchroman-6-yl)-5-methyl-2-(piperidin-1-yl)pyrazolo[1,5-a]pyrimidin-6-yl)acetic acid | 1454611-54-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: (2S)-2-(tert-butoxy)-2-(7-(8-fluoro-5-methylchroman-6-yl)-5-methyl-2-(piperidin-1-yl)pyrazolo[1,5-a]pyrimidin-6-yl)acetic acid
• 英文别名: (2S)-2-tert-butoxy-2-[7-(8-fluoro-5-methyl-chroman-6-yl)-5-methyl-2-(1-piperidyl)pyrazolo[1,5-a]pyrimidin-6-yl]acetic acid；(2S)-2-[7-(8-fluoro-5-methyl-3,4-dihydro-2H-chromen-6-yl)-5-methyl-2-piperidin-1-ylpyrazolo[1,5-a]pyrimidin-6-yl]-2-[(2-methylpropan-2-yl)oxy]acetic acid
• CAS: 1454611-54-1
• 化学式: C₂₈H₃₅FN₄O₄
• 分子量: 510.609
• InChiKey: MVBZMZQRIKBEAV-SANMLTNESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  37
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  89.2
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• [EN] HETEROCYCLYL COMPOUNDS AS MEK INHIBITORS<br/>[FR] COMPOSÉS HÉTÉROCYCLYLE EN TANT QU'INHIBITEURS DE MEK
  申请人：LUPIN LTD

  公开号：WO2013136249A1

  公开（公告）日：2013-09-19

  The present disclosure is related to heteroaryl compounds as MEK inhibitors. These compounds include heteroaryl compounds of Formula (I), their pharmaceutically acceptable salts, combinations with suitable medicament and pharmaceutical compositions thereof. The present disclosure also includes processes of preparation of the compounds and their use in methods of treatment. The compounds as disclosed herein are of Formula (I) below:

  本公开涉及杂环芳基化合物作为MEK抑制剂。这些化合物包括公式(I)的杂环芳基化合物，它们的药用盐，与适当药物的组合以及其制剂。本公开还包括这些化合物的制备方法和它们在治疗方法中的应用。本公开所披露的化合物如下所示：
• Inhibitors of Human Immunodeficiency Virus Replication
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20130237499A1

  公开（公告）日：2013-09-12

  The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV, pharmaceutical compositions containing such compounds, and methods for using these compounds in the treatment of HIV infection.

  该披露通常涉及到公式I的化合物，包括用于治疗人类免疫缺陷病毒（HIV）感染的组合物和方法。该披露提供了HIV的新型抑制剂，包含这些化合物的药物组合物，以及使用这些化合物治疗HIV感染的方法。
• INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION
  申请人：Bristol-Myers Squibb Company

  公开号：EP2822950A1

  公开（公告）日：2015-01-14
• HETEROCYCLYL COMPOUNDS AS MEK INHIBITORS
  申请人：Lupin Limited

  公开号：EP2834237A1

  公开（公告）日：2015-02-11
• US9006235B2
  申请人：——

  公开号：US9006235B2

  公开（公告）日：2015-04-14