4-(5-((1R,5S)-3-methyl-3,6-diazabicyclo[3.2.0]heptan-6-yl)pyridin-3-yl)-1H-indole tosylate | 1155870-21-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-(5-((1R,5S)-3-methyl-3,6-diazabicyclo[3.2.0]heptan-6-yl)pyridin-3-yl)-1H-indole tosylate
• 英文别名: 4-methylbenzenesulfonic acid;4-[5-[(1R,5S)-3-methyl-3,6-diazabicyclo[3.2.0]heptan-6-yl]pyridin-3-yl]-1H-indole
• CAS: 1155870-21-5
• 化学式: C₇H₈O₃S*C₁₉H₂₀N₄
• 分子量: 476.599
• InChiKey: UGVLQHVUBHQLCR-HNJSCFAESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.22
• 重原子数：
  34
• 可旋转键数：
  3
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  97.9
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• BIARYL SUBSTITUTED DIAZABICYCLOALKANE DERIVATIVES
  申请人：Ji Jianguo

  公开号：US20090197860A1

  公开（公告）日：2009-08-06

  The invention relates biaryl substituted diazabicycloalkanes, and more particularly bicycloheteroaryl substituted fused diazabicycloalkane derivatives, compositions comprising such compounds, and methods of preventing or treating conditions and disorders using such compounds and compositions.

  本发明涉及生物芳基取代的二氮杂双环烷，更具体地，涉及双环杂芳基取代的融合二氮杂双环烷衍生物，包括这些化合物的组合物，以及使用这些化合物和组合物预防或治疗疾病和症状的方法。
• N-Biaryl substituted diazabicycloalkane derivatives as agonists of the alpha7 and alpha4beta2 nACh Receptor
  申请人：AbbVie Inc.

  公开号：EP2604611A1

  公开（公告）日：2013-06-19

  The invention relates to biaryl substituted diazabicycloalkanes of formula (I), and more particularly bicycloheteroaryl substituted fused diazabicycloalkane derivatives, compositions comprising such compounds, and such compounds for use for treating or preventing conditions and disorders related to both α7 and α4β2 nAChR activity Formula: (I).

  本发明涉及式 (I) 的双芳基取代的重氮杂双环烷烃，尤其是双环杂芳基取代的融合重氮杂双环烷烃衍生物、包含此类化合物的组合物，以及用于治疗或预防与 α7 和 α4β2 nAChR 活性有关的病症和紊乱的此类化合物：(I).
• BIARYL SUBSTITUTED DIAZABICYCLOHEPTANE DERIVATIVES AS nAChR MODULATORS
  申请人：AbbVie Inc.

  公开号：EP2231672B1

  公开（公告）日：2014-12-17