(5-{[(1-3,3-dimethyl-2-oxobutyl)-6-methoxy-1H-indazol-3-yl]carbonyl}pyridine-2-yl)methyl dihydrogen phosphate | 848468-10-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡唑类
• 英文名称: (5-{[(1-3,3-dimethyl-2-oxobutyl)-6-methoxy-1H-indazol-3-yl]carbonyl}pyridine-2-yl)methyl dihydrogen phosphate
• 英文别名: [5-[1-(3,3-Dimethyl-2-oxobutyl)-6-methoxyindazole-3-carbonyl]pyridin-2-yl]methyl dihydrogen phosphate
• CAS: 848468-10-0
• 化学式: C₂₁H₂₄N₃O₇P
• 分子量: 461.411
• InChiKey: PZNXFQIJIWYXGH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  32
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  141
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• Ophthalmic compositions for treating ocular hypertension
  申请人：Chen Meng Hsin

  公开号：US20070010491A1

  公开（公告）日：2007-01-11

  This invention relates to potent potassium channel blocker compounds of Formula (I) or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans, or a pharmaceutically acceptable salt, in vivo hydrolysable ester, enantiomer, diastereomer or mixture thereof: formula (II) represents C 6-10 aryl or C 3-10 heterocyclyl, said aryl or heterocyclyl optionally substituted with 1-3 groups selected from R a ; Z represents (CH 2 ) n PO(OR)(OR*).
• US7410992B2
  申请人：——

  公开号：US7410992B2

  公开（公告）日：2008-08-12