| 1415222-58-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• CAS: 1415222-58-0
• 化学式: C₃₅H₂₄Br₂Cl₃NO₂PRe
• 分子量: 973.929
• InChiKey: UGTXGWPYZVCBTM-UHFFFAOYSA-K

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  5,7-二氯-8-羟基喹哪啶 以 乙腈 为溶剂， 反应 0.17h， 生成
  参考文献：
  名称：

  Contribution to investigation of antimicrobial activity of styrylquinolines

  摘要：

  Series of new ring-substituted styrylquinolines and two oxorhenium complexes were prepared and characterized. The compounds were analyzed using RP-HPLC to determine lipophilicity. Primary in vitro screening of the synthesized compounds was performed against fungal and bacterial strains. Some compounds were active against bacteria at micromolar level and against fungi at submicromolar level. Compounds 5,7-dichloro-2-[2-(2-ethoxyphenyl)vinyl]quinolin-8-ol expressed excellent antifungal activity comparable with or higher than the standard fluconazole as well as antibacterial activity against Staphylococcus strains comparable with or higher than the standards bacitracin, penicillin and ciprofloxacin. The structure-activity relationships are discussed. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2012.10.027