β-Naphthoesaeure-4'-amidinophenylester | 40761-79-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: β-Naphthoesaeure-4'-amidinophenylester
• 英文别名: (4-Carbamimidoylphenyl) naphthalene-2-carboxylate
• CAS: 40761-79-3
• 化学式: C₁₈H₁₄N₂O₂
• 分子量: 290.321
• InChiKey: CWTSYROMGPGVCF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  76.2
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Enzyme derivatives for use in the treatment of venous thrombosis, compositions containing them and their preparation
  申请人：BEECHAM GROUP PLC

  公开号：EP0009879A1

  公开（公告）日：1980-04-16

  A pharmaceutical composition which comprises a pharmaceutically acceptable carrier together with an in vivo fibrinolytic enzyme as defined herein wherein the catalytic site essential for fibrinolytic activity is blocked by a group which is removable by hydrolysis at a rate such that the pseudo-first order rate constant for hydrolysis is in the range 10-6 sec-1 to 10-3sec-1 in isotonic aqueous media at pH 7.4 at 37°C; is useful in the treatment of venous thrombosis.

  一种药物组合物，它包括药学上可接受的载体和本文定义的体内纤维蛋白溶解酶，其中纤维蛋白溶解活性所必需的催化位点被一个基团阻断，该基团可通过水解去除，水解的假一阶速率常数在 10-6 秒-1 到 10-3 秒-1 之间，在 37°C pH 值为 7.4 的等渗水介质中；该药物组合物可用于治疗静脉血栓。
• Enzyme derivatives, and their preparation
  申请人：BEECHAM GROUP PLC

  公开号：EP0028489A1

  公开（公告）日：1981-05-13

  An enzyme derivative comprises a binary complex between streptokinase and plasminogen in which the catalytic site essential for fibrinolytic activity is blocked by a group which is removable by hydrolysis such that the pseudo-first order rate constant for hydrolysis of the derivative is in the range 10-6sec-1to 10-3 sec-1 in isotonic aqueous media at pH 7.4 at 37°C, and is useful in the treatment of venous thrombosis.

  一种酶衍生物包括链激酶和纤溶酶原之间的二元复合物，其中对纤维蛋白溶解活性至关重要的催化位点被一个基团阻断，该基团可通过水解作用移除，因此在 37°C pH 值为 7.4 的等渗水介质中，该衍生物水解的假一阶速率常数在 10-6 秒-1 至 10-3 秒-1 之间，可用于治疗静脉血栓。
• ENZYME DERIVATIVES
  申请人：BEECHAM GROUP PLC

  公开号：EP0151593A1

  公开（公告）日：1985-08-21
• US4285932A
  申请人：——

  公开号：US4285932A

  公开（公告）日：1981-08-25
• US4337244A
  申请人：——

  公开号：US4337244A

  公开（公告）日：1982-06-29