methyl (2R,4S)-1-cyclohexylmethyl-4-[(1-hydroxy-naphthalene-2-carbonyl)-amino]-2-methyl-pyrrolidine-2-carboxylate | 1451055-47-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: methyl (2R,4S)-1-cyclohexylmethyl-4-[(1-hydroxy-naphthalene-2-carbonyl)-amino]-2-methyl-pyrrolidine-2-carboxylate
• 英文别名: methyl (2R,4S)-1-(cyclohexylmethyl)-4-[(1-hydroxynaphthalene-2-carbonyl)amino]pyrrolidine-2-carboxylate
• CAS: 1451055-47-2
• 化学式: C₂₄H₃₀N₂O₄
• 分子量: 410.513
• InChiKey: SHYCNVQYHJEFJJ-GHTZIAJQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  78.9
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] ANTIVIRAL COMPOUNDS<br/>[FR] COMPOSÉS ANTIVIRAUX
  申请人：HOFFMANN LA ROCHE

  公开号：WO2013124335A1

  公开（公告）日：2013-08-29

  The present invention provides compounds of formula I, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

  本发明提供了式I的化合物，用于治疗丙型肝炎病毒（HCV）感染的组合物和方法。还公开了含有这些化合物的药物组合物以及在治疗HCV感染中使用这些化合物的方法。
• ANTIVIRAL COMPOUNDS
  申请人：Hoffmann-La Roche Inc.

  公开号：US20150005283A1

  公开（公告）日：2015-01-01

  The present invention provides compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

  本发明提供了用于治疗丙型肝炎病毒（HCV）感染的化合物、组合物和方法。还公开了含有这些化合物的制药组合物以及使用这些化合物治疗HCV感染的方法。
• AMIDE COMPOUND AND USE THEREOF FOR PEST CONTROL
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：US20150005348A1

  公开（公告）日：2015-01-01

  An amide compound represented by formula (I) has an excellent pest control effect. (In the formula, Y represents a 3-7 membered saturated heterocyclic ring which contains, as ring-forming components(s), one or more atoms or groups that are selected from the group consisting of an oxygen atom and —S(O) t —, the saturated heterocyclic ring may have one to three atoms or groups selected from group D and t represents 0 or the like; x represents a C 1 -C 8 chain hydrocarbon group having one group that is selected from group A; W represents —CR 8 — or the like; r represents 1 or the like; R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 may be the same or different and each represents a hydrogen atom or the like; and n represents 1 or the like.)

  式(I)所代表的酰胺化合物具有出色的杀虫效果。（在该式中，Y代表一个含有3-7个饱和杂环环的结构，该结构中包含一个或多个从氧原子和-S(O)t-组成的原子或基团，饱和杂环环可能有一个到三个从D组成的原子或基团，t代表0或类似物；x代表一个C1-C8链烃基，其中有一个来自A组的基团；W代表-CR8-或类似物；r代表1或类似物；R1、R2、R3、R4、R5、R6、R7和R8可以相同也可以不同，每个代表一个氢原子或类似物；n代表1或类似物。）
• Antiviral Compounds
  申请人：Hoffmann-La Roche Inc.

  公开号：US20150274711A1

  公开（公告）日：2015-10-01

  The present invention provides compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

  本发明提供了用于治疗丙型肝炎病毒（HCV）感染的化合物、组合物和方法。还公开了含有这些化合物的药物组合物以及使用这些化合物治疗HCV感染的方法。
• US9090559B2
  申请人：——

  公开号：US9090559B2

  公开（公告）日：2015-07-28