N-[6-(4-fluoro-1H-indazol-6-yl)imidazo[1,2-a]pyrazin-8-yl]-6-(morpholin-4-yl)pyridin-3-amine | 1228795-95-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡唑类
• 英文名称: N-[6-(4-fluoro-1H-indazol-6-yl)imidazo[1,2-a]pyrazin-8-yl]-6-(morpholin-4-yl)pyridin-3-amine
• 英文别名: 6-(4-fluoro-1H-indazol-6-yl)-N-(6-morpholin-4-ylpyridin-3-yl)imidazo[1,2-a]pyrazin-8-amine
• CAS: 1228795-95-6
• 化学式: C₂₂H₁₉FN₈O
• 分子量: 430.444
• InChiKey: FFIRAJURARWRBR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  32
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  96.3
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• IMIDAZOPYRAZINE SYK INHIBITORS
  申请人：Mitchell Scott A.

  公开号：US20100152159A1

  公开（公告）日：2010-06-17

  Certain imidazopyrazines and pharmaceutical compositions thereof are provided herein. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of Syk activity, which comprises administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are provided. Also provided are methods for determining the presence or absence of Syk kinase in a sample.

  本文提供了某些咪唑吡嗪化合物及其药物组合物。提供了治疗对Syk活性抑制产生响应的某些疾病和疾病的患者的方法，包括向这些患者施用至少一种有效减少疾病或疾病症状的化学实体的数量。还提供了一种确定样本中Syk激酶存在或不存在的方法。
• IMIDAZOPYRIZINE SYK INHIBITORS
  申请人：Gilead Connecticut, Inc.

  公开号：US20130310363A1

  公开（公告）日：2013-11-21

  Certain imidazopyrazines of Formula (I): or pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof are provided herein. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of Syk activity, which comprises administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are provided. Also provided are methods for determining the presence or absence of Syk kinase in a sample.

  本文提供了公式（I）中的某些咪唑吡嗪化合物或其药学上可接受的盐以及其制药组合物。本文还提供了治疗对Syk活性抑制有反应的某些疾病和障碍的患者的方法，包括向这些患者施用至少一种有效减轻疾病或障碍症状的化学实体的数量。本文还提供了在样品中确定Syk激酶存在或不存在的方法。
• Composite resin particles and preparation thereof
  申请人：NIPPON PAINT CO., LTD.

  公开号：EP0409631A2

  公开（公告）日：1991-01-23

  The invention concerns a process for preparing composite resin particles having the so-called semi-IPN (inter penetration network) structure, in which linear thermoplastic polymer chains get entangled with a crosslinked polymer core through partial or thorough penetration. This method is important in that both of the chain polymer and core polymer are freely selected from various resins. Composite resin particles prepared by dispersing in an aqueous medium a uniform mixture of (A) a crosslinked structure-forming component having a number average molecular weight of about 180 to 1,000,000 selected from a resin having both dispersive power and cross linking property or a combination of two organic compounds each bearing mutually reactive functional groups which are required for the formation of crosslinked high molecular weight compound when said two compounds are reacted with each other, at least one of said organic compounds having dispersive power, and (B) a non -crosslinking thermoplastic resin which is not reactive with said (A) component, effecting a crosslinking of the crosslinked structure-­forming components in the dispersed particles, and removing the aqueous medium.

  本发明涉及一种制备具有所谓半 IPN（相互渗透网络）结构的复合树脂颗粒的工艺， 在这种结构中，线性热塑性聚合物链通过部分或完全渗透与交联聚合物芯缠结在一起。这种方法的重要之处在于，链聚合物和芯聚合物都可以从各种树脂中自由选择。 复合树脂颗粒的制备方法是将下列物质的均匀混合物分散在水介质中。 (A) 交联结构形成组分，其平均分子量在 180-1,000,000 之间，该组分可选自同时具有分散能力和交联特性的树脂，或两种有机化合物的组合，每种有机化合物都带有相互反应的官能团，当所述两种化合物相互反应时，需要这些官能团形成交联的高分子量化合物，所述有机化合物中至少有一种具有分散能力，和 (B) 非交联热塑性树脂，它与所述 (A) 组分不发生反应、 使分散颗粒中的交联结构形成成分发生交联，并除去水介质。
• Colored minute particles
  申请人：NIPPON SHOKUBAI CO., LTD.

  公开号：EP0823671A1

  公开（公告）日：1998-02-11

  A method which produces colored minute particles by suspending in an aqueous suspending medium a polymerizable monomer composition obtained by dispersing a coloring agent at least in a polymerizable monomer and polymerizing the resultant suspension is characterized in that the dispersion of the coloring agent in the polymerizable monomer is performed in the presence of a dispersing agent, the polymerizable monomer composition exhibits a viscosity of not more than 300 cP, and the suspension of the polymerizable monomer composition in the aqueous suspending medium exhibits a viscosity of not more than 100 cP. The dispersing agent is at least one resin selected from the group consisting of rosin derivatives, aromatic petroleum resins, pinene type resins, epoxy type resins, cumdrone resins, and styreneacryl type resins.

  一种通过将至少在可聚合单体中分散着色剂而得到的可聚合单体组合物悬浮在水性悬浮介质中，并使得到的悬浮液聚合而产生有色微粒的方法，其特征在于，着色剂在可聚合单体中的分散是在有分散剂存在的情况下进行的，可聚合单体组合物的粘度不超过300cP，可聚合单体组合物在水性悬浮介质中的悬浮液的粘度不超过100cP。分散剂为至少一种树脂，选自松香衍生物、芳香族石油树脂、蒎烯类树脂、环氧类树脂、积架树脂和苯乙烯丙烯类树脂组成的组。
• Inorganic dispersion stabilizer and process for producing resinous particles using the same
  申请人：NIPPON SHOKUBAI CO., LTD.

  公开号：EP0850984A1

  公开（公告）日：1998-07-01

  An inorganic dispersion stabilizer having a hydrophobic inorganic oxide such as hydrophobic silica dispersed in an aqueous medium in the presence of an hydrophilic organic compound such as alcohol. An suspension polymerization process for producing resinous particles of a narrow particle diameter distribution by dispersing a monomer into an dispersion medium in the presence of the inorganic dispersion stabilizer, and polymerizing the monomer.

  一种无机分散稳定剂，其中有一种疏水性无机氧化物，如疏水性二氧化硅，在亲水性有机化合物（如醇）存在下分散于水性介质中。一种悬浮聚合工艺，用于在无机分散稳定剂存在的情况下，将单体分散到分散介质中，并使单体聚合，从而生产出粒径分布较窄的树脂颗粒。