{(1R)-2-[(2S,4S)-2-{2'-[(2S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}pyrrolidine-2-yl]-1H,1'H-7,7'-binaphtho[1,2-d]imidazol-2-yl}-4-(methylsulfanyl)pyrrolidin-1-yl]-2-oxo-1-phenylethyl}carbamic acid methyl ester | 1377047-92-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: {(1R)-2-[(2S,4S)-2-{2'-[(2S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}pyrrolidine-2-yl]-1H,1'H-7,7'-binaphtho[1,2-d]imidazol-2-yl}-4-(methylsulfanyl)pyrrolidin-1-yl]-2-oxo-1-phenylethyl}carbamic acid methyl ester
• 英文别名: {(1R)-2-[(2S,4S)-2-{2'-[(2S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}pyrrolidin-2-yl]-1H,1'H-7,7'-binaphtho[1,2-d]imidazol-2-yl}-4-(methylsulfanyl)pyrrolidin-1-yl]-2-oxo-1-phenylethyl}carbamic acid methyl ester；methyl {(1R)-2-[(2S,4S)-2-{2'-[(2S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}pyrrolidin-2-yl]-1H,1'H-7,7'-binaphtho[1,2-d]imidazol-2-yl}-4-(methylsulfanyl)pyrrolidin-1-yl]-2-oxo-1-phenylethyl}carbamate；methyl N-[(1R)-2-[(2S,4S)-2-[7-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidin-2-yl]-3H-benzo[e]benzimidazol-7-yl]-3H-benzo[e]benzimidazol-2-yl]-4-methylsulfanylpyrrolidin-1-yl]-2-oxo-1-phenylethyl]carbamate
• CAS: 1377047-92-1
• 化学式: C₄₈H₅₀N₈O₆S
• 分子量: 867.041
• InChiKey: BOMJSBFKHZROGI-PKMXSZOSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.8
• 重原子数：
  63
• 可旋转键数：
  12
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  200
• 氢给体数：
  4
• 氢受体数：
  9

文献信息

• ANTIVIRAL COMPOUNDS
  申请人：Bacon Elizabeth M.

  公开号：US20140018313A1

  公开（公告）日：2014-01-16

  The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

  本发明涉及抗病毒化合物、含有这种化合物的组合物、包括给予这种化合物的治疗方法，以及用于制备这种化合物的有用过程和中间体。
• Antiviral compounds
  申请人：GILEAD PHARMASSET LLC

  公开号：US10344019B2

  公开（公告）日：2019-07-09

  The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

  本发明涉及抗病毒化合物、含有此类化合物的组合物、包括施用此类化合物的治疗方法，以及制备此类化合物的工艺和中间体。
• US9156823B2
  申请人：——

  公开号：US9156823B2

  公开（公告）日：2015-10-13
• [EN] ANTIVIRAL COMPOUNDS<br/>[FR] COMPOSÉS ANTIVIRAUX
  申请人：GILEAD SCIENCES INC

  公开号：WO2012068234A2

  公开（公告）日：2012-05-24

  The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.