4-甲基-6-(4-甲基哌嗪-1-基)嘧啶-2-基胺 | 5948-63-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 中文名称: 4-甲基-6-(4-甲基哌嗪-1-基)嘧啶-2-基胺
• 英文名称: UTSAM550
• 英文别名: 2-Amino-4-methyl-6-(N-methyl-piperazino)-pyrimidin；2-Amino-4-methyl-6-<4-methyl-piperazino>-pyrimidin；4-methyl-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylamine；4-Methyl-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine
• CAS: 5948-63-0
• 化学式: C₁₀H₁₇N₅
• 分子量: 207.278
• InChiKey: YUSOSBOKYGGFKB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  58.3
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  N-甲基哌嗪 、 2-氨基-4-氯-6-甲基嘧啶 在 三乙胺 作用下， 以 乙醇 为溶剂， 反应 16.0h， 以85%的产率得到4-甲基-6-(4-甲基哌嗪-1-基)嘧啶-2-基胺
  参考文献：
  名称：

  Structure−Activity Studies on a Series of a 2-Aminopyrimidine-Containing Histamine H₄ Receptor Ligands

  摘要：

  A series of 2-aminopyrimidines was synthesized as ligands of the histamine H-4 receptor (H4R). Working in part from a pyrimidine hit that was identified in an HTS campaign, SAR studies were carried out to optimize the potency, which led to compound 3,4-tert-butyl-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylamine. We further studied this compound by systematically modifying the core pyrimidine moiety, the methylpiperazine at position 4, the NH2 at position 2, and positions 5 and 6 of the pyrimidine ring. The pyrimidine 6 position benefited the most from this optimization, especially in analogs in which the 6-tert-butyl was replaced with aromatic and secondary amine moieties. The highlight of the optimization campaign was compound 4, 4-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]benzonitrile, which was potent in vitro and was active as an anti-inflammatory agent in an animal model and had antinociceptive activity in a pain model, which supports the potential of H4R antagonists in pain.

  DOI：

  10.1021/jm8005959

文献信息

• Method for Pain Treatment
  申请人：Cowart Marlon D.

  公开号：US20080194538A1

  公开（公告）日：2008-08-14

  This invention discloses a method of treating pain by administering histamine H 4 receptor ligands and compositions comprising the same.

  这项发明揭示了一种通过给予组织胺H4受体配体和包含相同的组合物来治疗疼痛的方法。
• 2-Aminopyrimidine modulators of the histamine H4 receptor
  申请人：Cai Hui

  公开号：US20080194577A1

  公开（公告）日：2008-08-14

  2-Aminopyrimidine compounds are described, which are useful as H 4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H 4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.

  描述了2-氨基嘧啶化合物，这些化合物可作为H4受体调节剂。这些化合物可用于制药组合物和治疗由H4受体活性介导的疾病状态、疾病和病况的方法，如过敏、哮喘、自身免疫疾病和瘙痒症。
• 2 Amino-Pyrimidine Derivatives As H4 Receptor Antagonists, Processes For Preparing Them And Their Use In Pharmaceutical Compositions
  申请人：Raphy Gilles

  公开号：US20100035863A1

  公开（公告）日：2010-02-11

  The present invention concerns novel 2 amino pyrimidine derivatives of formula (I), processes for preparing them, pharmaceutical compositions containing them and their use as harmaceuticals.

  本发明涉及式(I)的新型2-氨基嘧啶衍生物，制备它们的过程，含有它们的药物组合物以及它们作为药物的用途。
• 2-AMINOPYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR
  申请人：Cai Hui

  公开号：US20110218338A1

  公开（公告）日：2011-09-08

  2-Aminopyrimidine compounds are described, which are useful as H 4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H 4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritus.

  本文描述了2-氨基嘧啶化合物，这些化合物可用作H4受体调节剂。这些化合物可用于制备药物组合物和治疗疾病状态、障碍和条件的方法，这些状态、障碍和条件是由H4受体活性介导的，例如过敏、哮喘、自身免疫性疾病和瘙痒症。
• Dérivés de de la 6-méthyl-pyrimidine-2,4-diamine, procédé de synthèse, compositions les comprenant et utilisations comme agents neutralisants basiques
  申请人：L'OREAL

  公开号：EP1437348A1

  公开（公告）日：2004-07-14

  L'invention se rapporte à de nouveaux dérivés de la famille de la 6-méthyl-pyrimidine-2,4-diamine répondant à la formule (I) suivante : à leur procédé de synthèse, aux compositions cosmétiques ou pharmaceutiques les comprenant, ainsi qu'à leur utilisation comme agents neutralisants basiques ou comme agents conservateurs.

  本发明涉及与下式（I）相对应的 6-甲基嘧啶-2,4-二胺家族的新衍生物： 它们的合成工艺，含有它们的化妆品或药物组合物，以及它们作为碱性中和剂或防腐剂的用途。