4-dimethylamino-4'-isothiocyanostilbene | 73462-82-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 4-dimethylamino-4'-isothiocyanostilbene
• 英文别名: 4-Isocyanat-4'-dimethylamino-trans-stilben；Benzenamine, 4-[2-(4-isothiocyanatophenyl)ethenyl]-N,N-dimethyl-；4-[(E)-2-(4-isothiocyanatophenyl)ethenyl]-N,N-dimethylaniline
• CAS: 73462-82-5
• 化学式: C₁₇H₁₆N₂S
• 分子量: 280.393
• InChiKey: AELFAHXWAPNOLB-ONEGZZNKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  47.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-dimethylamino-4'-isothiocyanostilbene 、 聚甘氨酸 以 1,4-二氧六环 、 水 为溶剂， 生成 (3-{4-[(E)-2-(4-Dimethylamino-phenyl)-vinyl]-phenyl}-thioureido)-acetic acid
  参考文献：
  名称：

  Kuczek, Marian; Nowak, Kornel, Polish Journal of Chemistry, 1980, vol. 54, # 9, p. 1691 - 1696

  摘要：

  DOI：

文献信息

• Limited volume method and apparatus for particle counting
  申请人：SYVA COMPANY

  公开号：EP0099266A2

  公开（公告）日：1984-01-25

  A method and apparatus for determining the presence of particles in a fluorescent dispersion which exceed either a predetermined fluorescence intensity or size are disclosed. The method and apparatus involve the irradiation of the dispersion with excitation light, the examination of the fluorescent light entering an optical fiber from a portion of the excited region small enough to permit only a low probability that more than one particle of interest is present in the volume during a predetermined period of time, and the measurement of the emitted fluorescence entering the fiber, substantially free of excitation light, to the extent that the fluorescence differs in intensity from that of the dispersion in the absence of the particle.

  本发明公开了一种用于确定荧光分散体中是否存在超过预定荧光强度或尺寸的颗粒的方法和装置。该方法和装置包括：用激发光照射分散体；检查从激发区域的一个足够小的部分进入光纤的荧光，该部分小到只允许在预定的时间段内，在体积中存在一个以上的相关粒子的可能性很小；测量进入光纤的发射荧光，基本上不含激发光，荧光强度与没有粒子时的分散体的荧光强度相差多少。
• Atherosclerotic anti-idiotype antibody immunoassay and reagents
  申请人：VASOCOR

  公开号：EP0250119A2

  公开（公告）日：1987-12-23

  The method of this invention for determining the presence of atherosclerotic plaque antigen in serum comprises contacting the serum with anti-plaque antibody for a time sufficient to permit binding of the atherosclerotic plaque antigen with the anti-plaque antibody, and determining the atherosclerotic anti-idotype antibody, if any binding with the anti-plaque antibody. The anti-plaque antibody can be bound to an insoluble support, contacted with serum to permit atherosclerotic anti-idiotype antibody conjugation with the anti-plaque antibody, and the amount of resultant atherosclerotic anti-idiotype antibody bound to the insoluble support can be determined. Alternatively, a precise amount of atherosclerotic anti-idiotype antibody can be bound to the insoluble support, and a mixture of a predetermined excess amount of labeled anti-plaque antibody and serum can be contacted therewith. The labeled anti-plaque antibody bound to the insoluble support or remaining in the mixture can be determined. Also, a precise amount of anti-plaque antibody can be bound to the insoluble support, and a mixture of a predetermined amount of labeled atherosclerotic anti-idiotype antibody and serum contacted therewith. The labeled atherosclerotic anti-idiotype antibody bound to the insoluble support or remaining in the solution can then be determined.

  本发明用于确定血清中是否存在动脉粥样硬化斑块抗原的方法包括将血清与抗斑块抗体接触足够长的时间，以允许动脉粥样硬化斑块抗原与抗斑块抗体结合，并确定动脉粥样硬化抗同种型抗体（如果有的话）与抗斑块抗体结合。可将抗斑块抗体与不溶性支持物结合，然后与血清接触，使动脉粥样硬化抗原抗体与抗斑块抗体结合，最后测定与不溶性支持物结合的动脉粥样硬化抗原抗体的量。 或者，可以将精确量的动脉粥样硬化抗原抗体结合到不溶性支架上，然后将预定过量的标记抗斑块抗体和血清混合物与之接触。可以测定结合到不溶性支持物上或残留在混合物中的标记抗斑块抗体。此外，还可将精确量的抗斑块抗体结合到不溶性支持物上，并将预定量的标记动脉粥样硬化抗原抗体和血清的混合物与之接触。然后就可以测定结合到不溶性支持物上或残留在溶液中的标记的动脉粥样硬化抗原抗体。
• Atherosclerotic plaque antigen immunoassay
  申请人：VASOCOR

  公开号：EP0248630A2

  公开（公告）日：1987-12-09

  The method of this invention for determining the presence of atherosclerotic plaque antigen in serum comprises contacting the serum with anti-plaque antibody for a time sufficient to permit binding of the atherosclerotic plaque antigen with the anti-plaque antibody, and determining the atherosclerotic plaque antigen binding, if any, with the anti-plaque antibody. The anti-plaque antibody can be bound to an insoluble support, contacted with serum to permit atherosclerotic plaque antigen conjugation with the anti-plaque antibody, and the amount of resultant atherosclerotic plaque antigen bound to the insoluble support can be determined. Alternatively, a precise amount of atherosclerotic plaque antigen can be bound to the insoluble support, and a mixture of a predetermined excess amount of labeled anti-plaque antibody and serum can be contacted therewith. The labeled anti-plaque antibody bound to the insoluble support or remaining in the mixture can be determined. Also, a precise amount of anti-plaque antibody can be bound to the insoluble support, and a mixture of a predetermined amount of labeled atherosclerotic plaque antigen and serum contacted therewith. The labeled atherosclerotic plaque antigen bound to the insoluble support or remaining in the solution can then be determined.

  本发明用于确定血清中是否存在动脉粥样硬化斑块抗原的方法包括将血清与抗斑块抗体接触足够长的时间，以允许动脉粥样硬化斑块抗原与抗斑块抗体结合，并确定与抗斑块抗体结合的动脉粥样硬化斑块抗原（如果有）。可将抗斑块抗体与不溶性支持物结合，然后与血清接触，使动脉粥样硬化斑块抗原与抗斑块抗体结合，最后测定与不溶性支持物结合的动脉粥样硬化斑块抗原的量。 或者，可以将精确量的动脉粥样硬化斑块抗原结合到不溶性支持物上，然后将预定过量的标记抗斑块抗体和血清混合物与之接触。可以测定结合到不溶性支持物上或残留在混合物中的标记抗斑块抗体。此外，还可以将精确量的抗斑块抗体结合到不溶性支持物上，并将预定量的标记动脉粥样硬化斑块抗原和血清混合物与之接触。然后就可以确定结合到不溶性支持物上或残留在溶液中的标记动脉粥样硬化斑块抗原。
• Immunoassay for CK-MM isoenzymes
  申请人：INTERNATIONAL IMMUNOASSAY LABORATORIES, INC.

  公开号：EP0304628A2

  公开（公告）日：1989-03-01

  Methods and reagents for early detection of myocardial infarction determine the level of CK-MMA and the level of the combined CK-MMA and CK-MMB in in a serum sample. From these measurements, the time of the acute phase can be more accurately determined. Novel anti-(CK-MMA) antibodies, anti-(CK-MMB) antibodies, anti-(CK-MM(A+B)) antibodies, labeled and insolubilized derivatives of these antibodies, labeled MMA, and kits containing one or more of these reagents are also described.

  用于早期检测心肌梗死的方法和试剂可测定血清样本中 CK-MMA 的水平以及 CK-MMA 和 CK-MMB 的组合水平。通过这些测量结果，可以更准确地确定急性期的时间。此外，还介绍了新型抗（CK-MMA）抗体、抗（CK-MMB）抗体、抗（CK-MM（A+B））抗体、这些抗体的标记和未ubilized衍生物、标记的 MMA 以及含有一种或多种上述试剂的试剂盒。
• Vaginal sample test and reagents
  申请人：ADEZA BIOMEDICAL CORPORATION

  公开号：EP0316919A2

  公开（公告）日：1989-05-24

  Methods, reagents and kits for detection of normal or ectopic pregnancy, the termination of pregnancy, or increased risk of preterm labor and rupture of membranes. Each embodiment involves sampling from the vaginal cavity, and determining the presence or absence of a specific analyte in the test sample. Sandwich or competition assay procedures can be used. Reagents and reagent kits for the above assays are included.

  用于检测正常妊娠或宫外孕、终止妊娠或早产和胎膜破裂风险增加的方法、试剂和试剂盒。每个实施方案都涉及从阴道采样，并确定检测样本中是否存在特定的分析物。可使用夹心或竞争检测程序。包括用于上述检测的试剂和试剂盒。