1-methyl-1H-pyrazole-3-sulfonic acid benzyl-[2-(3-methoxypropionyl)-1,2,3,4-tetrahydroisoquinolin-6-yl]-amide | 1257583-17-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: 1-methyl-1H-pyrazole-3-sulfonic acid benzyl-[2-(3-methoxypropionyl)-1,2,3,4-tetrahydroisoquinolin-6-yl]-amide
• 英文别名: N-benzyl-N-[2-(3-methoxypropanoyl)-3,4-dihydro-1H-isoquinolin-6-yl]-1-methylpyrazole-3-sulfonamide
• CAS: 1257583-17-7
• 化学式: C₂₄H₂₈N₄O₄S
• 分子量: 468.577
• InChiKey: IJEXTKHNYPZQIA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  33
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  93.1
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• Compounds
  申请人：Hamlyn Richard John

  公开号：US20110136860A1

  公开（公告）日：2011-06-09

  A compound of formula (I): Or its salts or pharmaceutically acceptable derivatives thereof wherein: A represents a chemical moiety with the general formula (II): X and Y are independently selected from a group consisting of CH 2 , CH(R 5 ) or C(R 5 )(R 6 ); R 1 is selected from the group consisting of optionally substituted arylalkyl, and optionally substituted heteroarylalkyl; R 2 is selected from the group consisting of optionally substituted aryl or optionally substituted heteroaryl or NR 7 R 8 ; R 3 R 4 R 5 R 6 R 7 and R 8 are as defined herein, n=0, 1, 2 or 3; o=0, 1 or 2, with the proviso that when o=0, then n is 1, 2 or 3 and when o=1, then n is 1 or 2 is provided. Pharmaceutical compositions comprising the compounds are also provided. These compounds are useful in the treatment of various disorders including arrhythmia.

  化合物的化学式(I)：或其盐或药学上可接受的衍生物，其中：A代表具有通式(II)的化学基团：X和Y分别选自CH2、CH(R5)或C(R5)(R6)组成的一组；R1选自可选择取代的芳基烷基和可选择取代的杂环芳基烷基；R2选自可选择取代的芳基或可选择取代的杂环芳基或NR7R8；R3、R4、R5、R6、R7和R8如本文所定义；n=0、1、2或3；o=0、1或2，但当o=0时，n为1、2或3，当o=1时，n为1或2。同时还提供了包含这些化合物的药物组合物。这些化合物在治疗各种疾病，包括心律失常方面具有用途。
• DIHYDROINDOLE AND TETRAHYDROISOQUINOLINE DERIVATIVES USEFUL AS POTASSIUM CHANNEL INHIBITORS
  申请人：Japan Tobacco Inc.

  公开号：EP2438055B1

  公开（公告）日：2018-10-24
• US8426442B2
  申请人：——

  公开号：US8426442B2

  公开（公告）日：2013-04-23