8-oxo-5-(3,4,5-trimethoxy-phenyl)-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid | 114381-03-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 8-oxo-5-(3,4,5-trimethoxy-phenyl)-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid
• 英文别名: 1,2,3,4-tetrahydro-6,7-methylenedioxy-4-oxo-1-(3,4,5-trimethoxyphenyl)naphthalene-2-carboxylic acid；8-oxo-5-(3,4,5-trimethoxyphenyl)-6,7-dihydro-5H-benzo[f][1,3]benzodioxole-6-carboxylic acid
• CAS: 114381-03-2
• 化学式: C₂₁H₂₀O₈
• 分子量: 400.385
• InChiKey: OOLRAOZSVFPINR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  101
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  3,4-二氢-1(2H)-萘酮 、 8-oxo-5-(3,4,5-trimethoxy-phenyl)-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid 、 硼氢化钠 以, 82, 1714 (1960) to give the title compound as a crystalline solid的产率得到1,2,3,4-Tetrahydro-6,7-methylenedioxy-4-hydroxy-1-(3,4,5-trimethoxyphenyl)naphthalene-2-carboxylic acid
  参考文献：
  名称：

  Intermediates for the production of epipodophyllotoxin and related

  摘要：

  本发明提供了一种新颖高效的对映选择性全合成epipodoplyllotoxin和相关的epipodophyllotoxin化合物，其通式为##STR1##其中R.sup.1和R.sup.2各自独立地为氢或(较低的)烷氧基，或R.sup.1和R.sup.2共同为亚甲二氧基；R.sup.4和R.sup.6各自独立地为氢或(较低的)烷氧基；R.sup.5为氢或酚保护基；或其酸加成盐。本发明还提供了新的中间体和制备该中间体的方法，然后将其转化为已知的抗肿瘤剂。

  公开号：

  US04866189A1

文献信息

• Intermediates for the production of epipodophylotoxin and related
  申请人：Bristol-Myers Company

  公开号：US04728740A1

  公开（公告）日：1988-03-01

  There is provided a novel and efficient stereoselective total synthesis of epipodophyllotoxin and related epipodophyllotoxin compounds of the general formula ##STR1## wherein R.sup.1 and R.sup.2 each are independently hydrogen or (lower)alkoxy, or R.sup.1 and R.sup.2, taken together, is methylenedioxy; R.sup.4 and R.sup.6 each are independently hydrogen or (lower)alkoxy; and R.sup.5 is hydrogen or a phenol-protecting group; or an acid addition salt thereof. The present invention also provides novel intermediates and processes for the preparation of said intermediates, which are then converted into known antineoplastic agents.

  本发明提供了一种新颖和高效的立体选择性全合成环柿木毒素及相关环柿木毒素化合物，其一般式为##STR1##其中R.sup.1和R.sup.2各自独立地为氢或(较低)烷氧基，或R.sup.1和R.sup.2一起为亚甲二氧基；R.sup.4和R.sup.6各自独立地为氢或(较低)烷氧基；R.sup.5为氢或苯酚保护基；或其酸盐加合物。本发明还提供了新的中间体和制备该中间体的过程，然后将其转化为已知的抗肿瘤药物。
• Intermediates for the production of podophyllotoxin and related compounds and processes for the preparation and use thereof
  申请人：Bristol-Myers Squibb Company

  公开号：EP0224938A2

  公开（公告）日：1987-06-10

  There are disclosed intermediates which can be converted into podophyllotoxin and related compounds, which are known antineoplastic agents. There are also disclosed processes for the preparation of such intermediates, and processes for the conversion of the intermediates into known intermediates which are readily converted into podophyllotoxin and related compounds.

  已公开的中间体可转化为 podophyllotoxin 和相关化合物，它们是已知的抗肿瘤剂。此外，还公开了制备此类中间体的工艺，以及将中间体转化为已知中间体的工艺，这些中间体很容易转化为 podophyllotoxin 和相关化合物。
• US4644072A
  申请人：——

  公开号：US4644072A

  公开（公告）日：1987-02-17
• US4728740A
  申请人：——

  公开号：US4728740A

  公开（公告）日：1988-03-01
• US4734512A
  申请人：——

  公开号：US4734512A

  公开（公告）日：1988-03-29