3,2'-dichloro-deoxybenzoin | 717910-62-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 3,2'-dichloro-deoxybenzoin
• 英文别名: 3,2'-Dichlor-desoxybenzoin；2-(2-Chlorophenyl)-1-(3-chlorophenyl)ethanone
• CAS: 717910-62-8
• 化学式: C₁₄H₁₀Cl₂O
• mdl: MFCD12519483
• 分子量: 265.139
• InChiKey: HDZDRHYJZDIPIT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.071
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3,2'-dichloro-deoxybenzoin 生成 3,2'-dichloro-deoxybenzoin-seqtrans-oxime
  参考文献：
  名称：

  The Grignard Reaction in the Synthesis of Ketones. III. The Preparation and Characterization of a Series of Mono-and Dichlorodexosybenzoins

  摘要：

  DOI：

  10.1021/ja01334a045
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 哌啶 、 吡啶 、 水 作用下， 生成 3,2'-dichloro-deoxybenzoin
  参考文献：
  名称：

  Kroehnke; Vogt, Justus Liebigs Annalen der Chemie, 1954, vol. 589, p. 52

  摘要：

  DOI：

文献信息

• Pd-catalyzed synthesis of α-aryl ketones through couplings of α-arylacetyl chlorides with triarylbismuths as multi-coupling nucleophiles
  作者：Maddali L.N. Rao、Somnath Giri、Deepak N. Jadhav

  DOI：10.1016/j.tetlet.2009.08.074

  日期：2009.11

  The cross-coupling reaction of alpha-arylacetyl chlorides with triarylbismuths was studied under Pd-catalyzed conditions. The reaction was found to be facile under the established protocol and furnished high yields of alpha-aryl ketones in short reaction times. This work also demonstrated a facile synthesis of various regio-isomeric mono-, di- and tri-substituted alpha-aryl ketones in high yields. Triarylbisrnuths were employed as sub-stoichiometric multi-coupling organometallic nucleophiles in this coupling protocol. (C) 2009 Elsevier Ltd. All rights reserved.
• The Grignard Reaction in the Synthesis of Ketones. III. The Preparation and Characterization of a Series of Mono-and Dichlorodexosybenzoins
  作者：Sanford S. Jenkins

  DOI：10.1021/ja01334a045

  日期：1933.7
• Kroehnke; Vogt, Justus Liebigs Annalen der Chemie, 1954, vol. 589, p. 52
  作者：Kroehnke、Vogt

  DOI：——

  日期：——