2-(4-(5-(2-cyclopentyl-6-methoxypyridin-4-yl)-1,2,4-oxadiazol-3-yl)-2-ethyl-6-methylphenoxy)ethanamine | 1391465-66-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(4-(5-(2-cyclopentyl-6-methoxypyridin-4-yl)-1,2,4-oxadiazol-3-yl)-2-ethyl-6-methylphenoxy)ethanamine
• 英文别名: 2-[4-[5-(2-Cyclopentyl-6-methoxypyridin-4-yl)-1,2,4-oxadiazol-3-yl]-2-ethyl-6-methylphenoxy]ethanamine
• CAS: 1391465-66-9
• 化学式: C₂₄H₃₀N₄O₃
• 分子量: 422.527
• InChiKey: MNSCKYTVZLDPAN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  31
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  96.3
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• [EN] 2-METHOXY-PYRIDIN-4-YL DERIVATIVES<br/>[FR] DÉRIVÉS DE 2-METHOXY-PYRIDIN-4-YL
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2012098505A1

  公开（公告）日：2012-07-26

  The invention relates to pyridine derivatives of Formula (I) wherein A, R1, R2, R3, and R4 are as described in the description, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.

  该发明涉及式（I）的吡啶衍生物，其中A、R1、R2、R3和R4如描述中所述，它们的制备以及它们作为药用活性化合物的用途。这些化合物特别作为免疫调节剂。
• 2-METHOXY-PYRIDIN-4-YL-DERIVATIVES
  申请人：Bolli Martin

  公开号：US20130303514A1

  公开（公告）日：2013-11-14

  The invention relates to pyridine derivatives of Formula (I) wherein A, R 1 , R 2 , R 3 , and R 4 are as described in the description, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.

  该发明涉及公式（I）中的吡啶衍生物，其中A、R1、R2、R3和R4如描述中所述，它们的制备以及它们作为药用活性化合物的用途。这些化合物特别作为免疫调节剂。
• 2-METHOXY-PYRIDIN-4-YL DERIVATIVES
  申请人：Actelion Pharmaceuticals Ltd.

  公开号：EP2665720B1

  公开（公告）日：2015-06-10
• US9133179B2
  申请人：——

  公开号：US9133179B2

  公开（公告）日：2015-09-15