1-cyclopropyl-N-({1-[1-(pyridin-2-yl)cyclobutyl]-1,2,3,4-tetrahydroisoquinolin-7-yl}methyl)methanesulfonamide trifluoroacetate | 1190642-37-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: 1-cyclopropyl-N-({1-[1-(pyridin-2-yl)cyclobutyl]-1,2,3,4-tetrahydroisoquinolin-7-yl}methyl)methanesulfonamide trifluoroacetate
• 英文别名: 1-cyclopropyl-N-[[1-(1-pyridin-2-ylcyclobutyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]methyl]methanesulfonamide;2,2,2-trifluoroacetic acid
• CAS: 1190642-37-5
• 化学式: C₂HF₃O₂*C₂₃H₂₉N₃O₂S
• 分子量: 525.592
• InChiKey: TVTCJISLNNSAPX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.85
• 重原子数：
  36
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  117
• 氢给体数：
  3
• 氢受体数：
  10

文献信息

• TETRAHYDROISOQUINOLINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY
  申请人：Amberg Wilhelm

  公开号：US20110105502A1

  公开（公告）日：2011-05-05

  The present invention relates to tetrahydroisoquinoline of the formula (I) or a physiologically tolerated salt thereof. The invention relates to pharmaceutical compositions comprising such tetrahydroisoquinolines, and the use of such tetrahydroisoquinolines for therapeutic purposes. The tetrahydroisoquinolines are GlyT1 inhibitors.

  本发明涉及式(I)的四氢异喹啉或其生理上可耐受的盐。本发明涉及包含这种四氢异喹啉的药物组合物，以及使用这种四氢异喹啉进行治疗目的的用途。这些四氢异喹啉是GlyT1抑制剂。
• US8653100B2
  申请人：——

  公开号：US8653100B2

  公开（公告）日：2014-02-18
• [EN] TETRAHYDROISOQUINOLINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY<br/>[FR] TÉTRAHYDROISOQUINOLÉINES, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT ET LEUR UTILISATION EN THÉRAPIE
  申请人：ABBOTT GMBH & CO KG

  公开号：WO2009121872A2

  公开（公告）日：2009-10-08

  The present invention relates to tetrahydroisoquinoline of the formula (I) or a physiologically tolerated salt thereof. The invention relates to pharmaceutical compositions comprising such tetrahydroisoquinolines, and the use of such tetrahydroisoquinolines for therapeutic purposes. The tetrahydroisoquinolines are GIyT1 inhibitors.