3a(2)-Hydroxy-6a(2)-propoxyspiro[isobenzofuran-1(3H),9a(2)-[9H]xanthen]-3-one | 335193-90-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 3a(2)-Hydroxy-6a(2)-propoxyspiro[isobenzofuran-1(3H),9a(2)-[9H]xanthen]-3-one
• 英文别名: 3'-hydroxy-6'-propoxyspiro[2-benzofuran-3,9'-xanthene]-1-one
• CAS: 335193-90-3
• 化学式: C₂₃H₁₈O₅
• 分子量: 374.4
• InChiKey: KQEPAKWLRGXVEX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  65
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] TACCALONOLIDE MICROTUBULE STABILIZERS<br/>[FR] STABILISATEURS TACCALONOLIDES DE MICROTUBULES
  申请人：UNIV TEXAS

  公开号：WO2018112391A1

  公开（公告）日：2018-06-21

  The present disclosure relates to the fields of medicine and pharmaceuticals. In particular, the invention relates to the identification of epoxytaccalonolide microtubule stabilizers for use in inhibiting cell proliferation and disrupting normal cellular microtubule processes leading to cell death. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.