5-(Piperazin-1-YL)furan-2-carbaldehyde | 1094311-40-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 5-(Piperazin-1-YL)furan-2-carbaldehyde
• 英文别名: 5-piperazin-1-ylfuran-2-carbaldehyde
• CAS: 1094311-40-6
• 化学式: C₉H₁₂N₂O₂
• 分子量: 180.206
• InChiKey: ZNKMSGPIGUSWNY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  45.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  哌嗪 、 5-溴-2-呋喃甲醛 在 三乙胺 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 4.0h， 生成 5-(Piperazin-1-YL)furan-2-carbaldehyde
  参考文献：
  名称：

  From Furans to Anilines:  Toward One-Pot Two-Step Amination/Diels−Alder Sequences

  摘要：

  Selective metal-free amination and Diels-Alder reactions are described in the furan series, leading to polysubstituted anilines or to stable oxabicyclic adducts in high yield. Interestingly, anilines are conveniently prepared through a novel one-pot, two-step amination/Diels-Alder procedure from commercially available 5-bromo-2-furaldehyde.

  DOI：

  10.1021/jo7024916

文献信息

• From Furans to Anilines:  Toward One-Pot Two-Step Amination/Diels−Alder Sequences
  作者：Raouf Medimagh、Sylvain Marque、Damien Prim、Saber Chatti、Hédi Zarrouk

  DOI：10.1021/jo7024916

  日期：2008.3.1

  Selective metal-free amination and Diels-Alder reactions are described in the furan series, leading to polysubstituted anilines or to stable oxabicyclic adducts in high yield. Interestingly, anilines are conveniently prepared through a novel one-pot, two-step amination/Diels-Alder procedure from commercially available 5-bromo-2-furaldehyde.