5-[(4-methoxy-6-chloro-s-triazin-2-yl)-amino]-fluorescein | 105299-78-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 5-[(4-methoxy-6-chloro-s-triazin-2-yl)-amino]-fluorescein
• 英文别名: 6-[(4-Chloro-6-methoxy-1,3,5-triazin-2-yl)amino]-3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one
• CAS: 105299-78-3
• 化学式: C₂₄H₁₅ClN₄O₆
• 分子量: 490.859
• InChiKey: NTUSRASMZIOSKM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  35
• 可旋转键数：
  3
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  136
• 氢给体数：
  3
• 氢受体数：
  10

文献信息

• Tracers for disopyramide assay and immunogens to raise antibody
  申请人：ABBOTT LABORATORIES

  公开号：EP0184120A2

  公开（公告）日：1986-06-11

  This invention relates to an improved fluorescent polarization assay for disopyramide, and to improved reagents (tracer compounds and immunogen) for use in the assay. The 10 tracer compounds are the reaction product of p- or m-aminodisopyramide with 10 fluorescein compounds. The tracers form complexes with antiserum specific to disopyramide, in proportion to the relative concentration of the tracer with respect to the disopyramide present in the sample. Excellent results are obtained when such a tracer compound is used in fluorescent polarization assay for disopyramide, with greater speed and less cross-reactivity than prior art methods of immunoassay.

  本发明涉及一种改进的荧光偏振测定法，用于测定地索比酰胺和改进的试剂（示踪化合物和免疫原）。10 种示踪化合物是对氨基或间氨基异吡酰胺与 10 种荧光素化合物的反应产物。示踪剂与抗血清特异性地形成复合物，复合物与示踪剂相对于样品中二吡酰胺的相对浓度成比例。与现有技术的免疫测定方法相比，这种示踪化合物在荧光偏振法测定地辛酰胺时，速度更快，交叉反应更少，可获得极佳的结果。
• Substituted anilide compounds and their use
  申请人：ABBOTT LABORATORIES

  公开号：EP0201633A2

  公开（公告）日：1986-11-20

  The present invention is directed to a fluorescent polarization assay for acetaminophen, to the various components needed for preparing and carrying out such an assay, and to methods of making these components. Specifically, tracers, immunogens and antibodies are disclosed, as well as methods for making them. The tracers and the immunogens are made from substituted anilide compounds. A fluorescein moiety is included in the tracer, while a poly-(amino acid) forms a part of the immunogen. The antibodies are prepared in response to the immunogen. The assay is conducted by measuring the degree of polarization retention of plane polarized light that has been passed through a sample containing antiserum and tracer.

  本发明涉及对乙酰氨基酚的荧光偏振测定法、制备和实施这种测定法所需的各种成分以及制备这些成分的方法。 具体而言，本发明公开了示踪剂、免疫原和抗体以及制备它们的方法。 示踪剂和免疫原由取代的苯胺化合物制成。 示踪剂中含有荧光素分子，而聚氨基酸则是免疫原的一部分。 抗体是针对免疫原制备的。 该测定法是通过测量穿过含有抗血清和示踪剂的样品的平面偏振光的偏振保留程度来进行的。
• Tracers for use in flecainide fluorescence polarization immunoassay
  申请人：ABBOTT LABORATORIES

  公开号：EP0242847A2

  公开（公告）日：1987-10-28

  The present invention is directed to a fluorescence polarization assay for determining the amount of flecainide in fluids, especially biological fluids such as serum, plasma or urine. The present invention also relates to novel tracer compounds useful in fluorescence polarization assay techniques.

  本发明涉及一种荧光偏振测定法，用于确定体液，特别是血清、血浆或尿液等生物体液中的非加尼含量。 本发明还涉及可用于荧光偏振测定技术的新型示踪化合物。
• US5051361A
  申请人：——

  公开号：US5051361A

  公开（公告）日：1991-09-24
• US5336622A
  申请人：——

  公开号：US5336622A

  公开（公告）日：1994-08-09