ethyl (2S,4S)-1-cyclobutylmethyl-4-[(1-hydroxy-naphthalene-2-carbonyl)-amino]-pyrrolidine-2-carboxylate | 1451055-33-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: ethyl (2S,4S)-1-cyclobutylmethyl-4-[(1-hydroxy-naphthalene-2-carbonyl)-amino]-pyrrolidine-2-carboxylate
• 英文别名: (2S,4S)-1-Cyclobutylmethyl-4-[(1-hydroxy-naphthalene-2-carbonyl)-amino]-pyrrolidine-2-carboxylic acid ethyl ester；ethyl (2S,4S)-1-(cyclobutylmethyl)-4-[(1-hydroxynaphthalene-2-carbonyl)amino]pyrrolidine-2-carboxylate
• CAS: 1451055-33-6
• 化学式: C₂₃H₂₈N₂O₄
• 分子量: 396.486
• InChiKey: GTKFJPBDXNIJIQ-PXNSSMCTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  78.9
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (2S,4S)-4-Amino-1-cyclobutylmethyl-pyrrolidine-2-carboxylic acid ethyl ester 、 1-羟基-2-萘甲酸 生成 ethyl (2S,4S)-1-cyclobutylmethyl-4-[(1-hydroxy-naphthalene-2-carbonyl)-amino]-pyrrolidine-2-carboxylate
  参考文献：
  名称：

  Antiviral compounds

  摘要：

  本发明提供了用于治疗丙型肝炎病毒（HCV）感染的化合物、组合物和方法。还公开了含有这些化合物的制药组合物以及使用这些化合物治疗HCV感染的方法。

  公开号：

  US09090559B2

文献信息

• [EN] ANTIVIRAL COMPOUNDS<br/>[FR] COMPOSÉS ANTIVIRAUX
  申请人：HOFFMANN LA ROCHE

  公开号：WO2013124335A1

  公开（公告）日：2013-08-29

  The present invention provides compounds of formula I, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

  本发明提供了式I的化合物，用于治疗丙型肝炎病毒（HCV）感染的组合物和方法。还公开了含有这些化合物的药物组合物以及在治疗HCV感染中使用这些化合物的方法。
• ANTIVIRAL COMPOUNDS
  申请人：Hoffmann-La Roche Inc.

  公开号：US20150005283A1

  公开（公告）日：2015-01-01

  The present invention provides compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

  本发明提供了用于治疗丙型肝炎病毒（HCV）感染的化合物、组合物和方法。还公开了含有这些化合物的制药组合物以及使用这些化合物治疗HCV感染的方法。
• AMIDE COMPOUND AND USE THEREOF FOR PEST CONTROL
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：US20150005348A1

  公开（公告）日：2015-01-01

  An amide compound represented by formula (I) has an excellent pest control effect. (In the formula, Y represents a 3-7 membered saturated heterocyclic ring which contains, as ring-forming components(s), one or more atoms or groups that are selected from the group consisting of an oxygen atom and —S(O) t —, the saturated heterocyclic ring may have one to three atoms or groups selected from group D and t represents 0 or the like; x represents a C 1 -C 8 chain hydrocarbon group having one group that is selected from group A; W represents —CR 8 — or the like; r represents 1 or the like; R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 may be the same or different and each represents a hydrogen atom or the like; and n represents 1 or the like.)

  式(I)所代表的酰胺化合物具有出色的杀虫效果。（在该式中，Y代表一个含有3-7个饱和杂环环的结构，该结构中包含一个或多个从氧原子和-S(O)t-组成的原子或基团，饱和杂环环可能有一个到三个从D组成的原子或基团，t代表0或类似物；x代表一个C1-C8链烃基，其中有一个来自A组的基团；W代表-CR8-或类似物；r代表1或类似物；R1、R2、R3、R4、R5、R6、R7和R8可以相同也可以不同，每个代表一个氢原子或类似物；n代表1或类似物。）
• Antiviral Compounds
  申请人：Hoffmann-La Roche Inc.

  公开号：US20150274711A1

  公开（公告）日：2015-10-01

  The present invention provides compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

  本发明提供了用于治疗丙型肝炎病毒（HCV）感染的化合物、组合物和方法。还公开了含有这些化合物的药物组合物以及使用这些化合物治疗HCV感染的方法。
• METHOD FOR CONTROLLING ARTHROPOD PEST
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP2952096A1

  公开（公告）日：2015-12-09

  An amide compound represented by formula (I): [wherein A represents a 3- to 7-membered saturated heterocyclic ring which contains, as ring-forming component(s), one or more atoms or groups selected from the group consisting of an oxygen atom and -S(O)t-, t represents 0, etc., R1 and R2 are the same or different and represent a hydrogen atom, etc., n represents 0, etc., the following formula (II): represents a 5-membered aromatic ring, in which Z represents a nitrogen atom or a carbon atom and X1, X2 and X3 are the same or different and represent a nitrogen atom, etc., R3 and R4 are the same or different and represent a hydrogen atom, etc., m represents 0 to 2, Q represents one group selected from group A or a C1 to C8 chain hydrocarbon group optionally having one group selected from group A, Y represents an oxygen atom, etc. , u represents 0, etc., and v represents 0, etc.] has excellent arthropod pest controlling effects.

  式 (I) 所代表的酰胺化合物： [其中 A 代表 3 至 7 元饱和杂环，该环作为成环组分含有一个或多个原子或基团，这些原子或基团选自由氧原子和-S(O)t-组成的组，t 代表 0 等，R1 和 R2 相同或不同，代表氢原子等，n 代表 0 等，下式（II）： 代表 5 元芳香环，其中 Z 代表氮原子或碳原子，X1、X2 和 X3 相同或不同并代表氮原子等，R3 和 R4 相同或不同并代表氢原子等，m 代表 0 至 2，Q 代表选自 A 组的一个基团或任选具有一个选自 A 组的基团的 C1 至 C8 链烃基，Y 代表氧原子等。u 代表 0 等，v 代表 0 等]具有很好的节肢动物害虫防治效果。