3-bromo-4-(naphthalen-1-ylamino)furan-2(5H)-one | 1310679-32-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 3-bromo-4-(naphthalen-1-ylamino)furan-2(5H)-one
• CAS: 1310679-32-3
• 化学式: C₁₄H₁₀BrNO₂
• 分子量: 304.143
• InChiKey: UTBNWORNFHKQML-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.42
• 重原子数：
  18.0
• 可旋转键数：
  2.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  38.33
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  3,4-二溴呋喃-2(5H)-酮 、 1-萘胺 以 甲醇 为溶剂， 反应 168.0h， 以57%的产率得到3-bromo-4-(naphthalen-1-ylamino)furan-2(5H)-one
  参考文献：
  名称：

  Synthesis of 3-bromotetronamides via amination of 3,4-dibromofuran-2(5H)-one

  摘要：

  This work describes the direct synthesis of 3-bromotetronamides in good yields through the reaction of 3,4-dibromofuran-2(5H)-one, obtained from furfural, with primary and secondary amines. Aromatic amines were more tolerated than aliphatic and heteroaromatic ones. The X-ray structures of five derivatives are described.

  DOI：

  10.1590/s0103-50532011000300026

文献信息

• Synthesis of 3-bromotetronamides via amination of 3,4-dibromofuran-2(5H)-one
  作者：Silvio Cunha、Caio C Oliveira、José R Sabino

  DOI：10.1590/s0103-50532011000300026

  日期：——

  This work describes the direct synthesis of 3-bromotetronamides in good yields through the reaction of 3,4-dibromofuran-2(5H)-one, obtained from furfural, with primary and secondary amines. Aromatic amines were more tolerated than aliphatic and heteroaromatic ones. The X-ray structures of five derivatives are described.