(1S,2R)-2-(t-butyldiphenylsilyloxy)methyl-1-(2-hydroxyethyl)cyclopropane | 1449741-34-7

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: (1S,2R)-2-(t-butyldiphenylsilyloxy)methyl-1-(2-hydroxyethyl)cyclopropane
• CAS: 1449741-34-7
• 化学式: C₂₂H₃₀O₂Si
• 分子量: 354.565
• InChiKey: UDFHLMZCBVUMCL-MOPGFXCFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.58
• 重原子数：
  25.0
• 可旋转键数：
  7.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  29.46
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  (1S,2R)-2-(t-butyldiphenylsilyloxy)methyl-1-(2-hydroxyethyl)cyclopropane 在 四丁基氟化铵 、 四丁基碘化铵 、 sodium hydride 、 戴斯-马丁氧化剂 作用下， 以 四氢呋喃 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 30.75h， 生成 (1S,2R)-trans-1-(2-benzyloxy)ethyl-2-carboxycyclopropane
  参考文献：
  名称：

  Cyclopropane-based conformational restriction of GABA by a stereochemical diversity-oriented strategy: Identification of an efficient lead for potent inhibitors of GABA transports

  摘要：

  A series of cyclopropane-based conformationally restricted gamma-aminobutyric acid (GABA) analogs with stereochemical diversity, that is, the trans- and cis-2,3-methano analogs Ia and Ib and their enantiomers ent-Ia and ent-Ib, and also the trans- and cis-3,4-methano analogs IIa and IIb and their enantiomers ent-IIa and ent-Iib, were synthesized from the chiral cyclopropane units Type-a and Type-b that we developed. These analogs were systematically evaluated with four GABA transporter (GAT) subtypes. The trans-3,4-methano analog IIa had inhibitory effects on GAT3 (IC50 = 23.9 mu M) and betaine-GABA transporter1 (5.48 mu M), indicating its potential as an effective lead compound for the development of potent GAT inhibitors due to its hydrophilic and low molecular weight properties and excellent ligand efficiency. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2013.06.063
• 作为产物：
  描述：

  甲氧基甲基三苯基氯化膦 、 (1R,2R)-2-(tert-butyldiphenylsilyloxy)methyl-1-formylcyclopropane 在 sodium hexamethyldisilazane 、 盐酸 、 sodium tetrahydroborate 作用下， 以 四氢呋喃 、 水 、 甲醇 为溶剂， 反应 8.58h， 以66%的产率得到(1S,2R)-2-(t-butyldiphenylsilyloxy)methyl-1-(2-hydroxyethyl)cyclopropane
  参考文献：
  名称：

  Cyclopropane-based conformational restriction of GABA by a stereochemical diversity-oriented strategy: Identification of an efficient lead for potent inhibitors of GABA transports

  摘要：

  A series of cyclopropane-based conformationally restricted gamma-aminobutyric acid (GABA) analogs with stereochemical diversity, that is, the trans- and cis-2,3-methano analogs Ia and Ib and their enantiomers ent-Ia and ent-Ib, and also the trans- and cis-3,4-methano analogs IIa and IIb and their enantiomers ent-IIa and ent-Iib, were synthesized from the chiral cyclopropane units Type-a and Type-b that we developed. These analogs were systematically evaluated with four GABA transporter (GAT) subtypes. The trans-3,4-methano analog IIa had inhibitory effects on GAT3 (IC50 = 23.9 mu M) and betaine-GABA transporter1 (5.48 mu M), indicating its potential as an effective lead compound for the development of potent GAT inhibitors due to its hydrophilic and low molecular weight properties and excellent ligand efficiency. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2013.06.063