6-ethyl-3-phenyl-1,2,4,5-tetrazine | 76630-73-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四嗪
• 英文名称: 6-ethyl-3-phenyl-1,2,4,5-tetrazine
• 英文别名: 3-Ethyl-6-phenyl-1,2,4,5-tetrazine
• CAS: 76630-73-4
• 化学式: C₁₀H₁₀N₄
• 分子量: 186.216
• InChiKey: VTYLHCJPTVZISB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  51.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6-ethyl-3-phenyl-1,2,4,5-tetrazine 在 sodium tetrahydroborate 作用下， 以 乙醇 、 氯仿 、 水 为溶剂， 反应 0.25h， 以55%的产率得到6-ethyl-3-phenyl-1,6-dihydro-1,2,4,5-tetrazine
  参考文献：
  名称：

  1,6-Dihydro-1,2,4,5-tetrazine, a neutral homoaromatic system

  摘要：

  DOI：

  10.1021/jo00323a032
• 作为产物：
  描述：

  苯甲亚胺酸乙酯盐酸盐 、 丙脒盐酸盐 在 氧气 、 一水合肼 作用下， 生成 6-ethyl-3-phenyl-1,2,4,5-tetrazine
  参考文献：
  名称：

  1,6-Dihydro-1,2,4,5-tetrazine, a neutral homoaromatic system

  摘要：

  DOI：

  10.1021/jo00323a032

文献信息

• Triple aryne–tetrazine reaction enabling rapid access to a new class of polyaromatic heterocycles
  作者：Sung-Eun Suh、Stephanie A. Barros、David M. Chenoweth

  DOI：10.1039/c5sc01726b

  日期：——

  We report the triple aryne–tetrazine reaction for rapid access to a new class of dibenzocinnoline heteroaromatics.

  我们报道了三联芳炔-四氮杂环反应，以快速获得一类新的二苯并咪唑杂环化合物。
• COUNOTTE-POTMAN A.; PLAS H. C. VAN DER; VELDHUIZEN B. VAN, J. ORG. CHEM., 1981, 46, NO 10, 2138-2141
  作者：COUNOTTE-POTMAN A.、 PLAS H. C. VAN DER、 VELDHUIZEN B. VAN

  DOI：——

  日期：——
• SUN, XI-CHENG;REN, GUO-DU, YUTSZU XUASYUEH, 8,(1988) N 4, S. 365-368
  作者：SUN, XI-CHENG、REN, GUO-DU

  DOI：——

  日期：——
• MULTIFUNCTIONALIZED POLYETHYLENE GLYCOL DERIVATIVE AND PREPARATION METHOD THEREFOR
  申请人：XIAMEN SINOPEG BIOTECH CO., LTD.

  公开号：US20170312363A1

  公开（公告）日：2017-11-02

  Disclosed are a multifunctionalized polyethylene glycol derivative and a preparation method therefor. The derivative has an H-shaped structure as represented by formula (1) and comprises one linear core LPEG and four PEG branch chains, where n 1 , n 2 , n 3 , and n 4 respectively are the degrees of polymerization of the branch chains, U 1 and U 2 are trivalent branching groups connecting the core LPEG to two of the PEG branch chains, F 1 and F 2 contain a functional group or a protected form R 01 thereof and may or may not contain a branched group G, correspondingly, the number of R 01 is one or more, F 1 and F 2 are either identical or different, any one linking group in the molecule or any linking group formed with an adjacent heteroatom group can either remain stable or be degraded, and any one PEG segment in the molecule is discretely polydispersed or monodispersed. The multifunctional polyethylene glycol is flexible and diverse in terms of branch structures and the lengths of branching arms, has various parameters and performance indicators that are adjustable and easy to control, and has a broad applicability.
• EIGHT-ARM POLYETHYLENE GLYCOL DERIVATIVE, PRODUCTION METHOD THEREFOR, AND MODIFIEDBIO-RELATEDSUBSTANCETHEREOF
  申请人：XIAMEN SINOPEG BIOTECH CO., LTD

  公开号：US20180214561A1

  公开（公告）日：2018-08-02

  Disclosed are an eight-arm polyethylene glycol (PEG) derivative (formula I), production method therefor and modified bio-related substance thereby. Wherein, one tetravalent group U together with four trivalent groups E c form a highly symmetrical octavalent group CORE 0 ; L c connects the octavalent group to eight PEG chains having polydispersity or monodispersity and having n 1 to n 8 as the degree of polymerization thereof; the terminal of one PEG chain is connected to at least one functional group F (k≥1); said PEG chain and F therebetween can be directly connected (g=0) or be indirectly connected via a linking group L 0 to a terminal end-branching group G (g=1); the latter provides more reactive sites for binding more drug molecules and increases the drug loading. The eight-arm polyethylene glycol derivative has a centrosymmetric or approximately centrosymmetric structure, and leads to more precise control of the molecular weight in large-scale production and much narrower distribution of molecular weight for products. The modified bio-related substance thereby has a more uniform and controllable performance.