4-[(2-dimethylamino-ethylamino)-methyl]-piperidine-1-carboxylic acid tert-butyl ester | 832716-10-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-[(2-dimethylamino-ethylamino)-methyl]-piperidine-1-carboxylic acid tert-butyl ester
• 英文别名: 4-[[[2-(dimethylamino)ethyl]amino]methyl]-1-(tert-butoxycarbonyl)piperidine；tert-butyl 4-[[2-(dimethylamino)ethylamino]methyl]piperidine-1-carboxylate
• CAS: 832716-10-6
• 化学式: C₁₅H₃₁N₃O₂
• 分子量: 285.43
• InChiKey: TWOLPNTVDLWWBI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  20
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  44.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-[(2-dimethylamino-ethylamino)-methyl]-piperidine-1-carboxylic acid tert-butyl ester 、 乙酰氯 在 N-(methylpolystyrene)-4-(methylamino)pyridine (PS-DMAP) 作用下， 以 二氯甲烷 为溶剂， 反应 18.0h， 生成 4-[[N-acetyl-N-[2-(dimethyamino)ethyl]amino]methyl]-1-(tert-butoxycarbonyl)piperidine
  参考文献：
  名称：

  EP1772454

  摘要：

  公开号：
• 作为产物：
  描述：

  N,N-二甲基乙二胺 、 1-叔丁氧羰基哌啶-4-甲醛 在 三乙酰氧基硼氢化钠 、 溶剂黄146 作用下， 以 氯仿 为溶剂， 反应 24.0h， 生成 4-[(2-dimethylamino-ethylamino)-methyl]-piperidine-1-carboxylic acid tert-butyl ester
  参考文献：
  名称：

  EP1772454

  摘要：

  公开号：

文献信息

• Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto
  申请人：Jones M. Robert

  公开号：US20060142262A1

  公开（公告）日：2006-06-29

  The present invention relates to certain fused aryl and heteroaryl derivatives of Formula (I) that are modulators of metabolism. Accordingly, compounds of the present invention are useful in the prophylaxis or treatment of metabolic disorders and complications thereof, such as, diabetes and obesity.

  本发明涉及公式（I）的某些融合芳基和杂芳基衍生物，它们是代谢调节剂。因此，本发明的化合物在预防或治疗代谢性疾病及其并发症方面非常有用，如糖尿病和肥胖症。
• Nitrogenous Fused Bicyclic Compound
  申请人：Takamuro Iwao

  公开号：US20080081817A1

  公开（公告）日：2008-04-03

  A novel nitrogenous fused bicyclic compound represented by the following general formula [1] or a pharmacologically acceptable salt of the compound. They have excellent SK channel blocking activity and are useful as a medicine. [I] (In the formula, R 0 represents hydrogen, halogeno, etc.; R 1 represents a group represented by the formula (a) or (b); A represents a group represented by the formula (X) or (Y); D 1 , D 2 and D 3 each represents N or CH; R 2 represents halogeno or optionally halogenated lower alkyl, etc.; R 3 represents hydrogen or lower alkyl; and Q represents lower alkylene.)

  下面是一种新型的含氮融合双环化合物，其通式如下[1]，或其药理学上可接受的盐。它们具有出色的SK通道阻滞活性，是一种有用的药物。[I]（在公式中，R0代表氢，卤素等; R1代表由公式（a）或（b）表示的基团; A代表由公式（X）或（Y）表示的基团; D1，D2和D3分别表示N或CH; R2代表卤素或可选卤代的低碳基等; R3代表氢或低碳基; Q代表低碳链基）。
• FUSED-ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO
  申请人：Jones Robert M.

  公开号：US20100093761A1

  公开（公告）日：2010-04-15

  The present invention relates to certain fused aryl and heteroaryl derivatives of Formula (I) that are modulators of metabolism. Accordingly, compounds of the present invention are useful in the prophylaxis or treatment of metabolic disorders and complications thereof, such as, diabetes and obesity.

  本发明涉及公式（I）的某些融合芳基和杂环芳基衍生物，它们是代谢调节剂。因此，本发明的化合物在预防或治疗代谢性疾病及其并发症，如糖尿病和肥胖症方面是有用的。
• NITROGENOUS FUSED BICYCLIC COMPOUND
  申请人：TANABE SEIYAKU CO., LTD.

  公开号：EP1772454A1

  公开（公告）日：2007-04-11

  A novel nitrogenous fused bicyclic compound represented by the following general formula [1] or a pharmacologically acceptable salt of the compound. They have excellent SK channel blocking activity and are useful as a medicine. [I] (In the formula, R0 represents hydrogen, halogeno, etc.; R1 represents a group represented by the formula (a) or (b); A represents a group represented by the formula (X) or (Y); D1, D2 and D3 each represents N or CH; R2 represents halogeno or optionally halogenated lower alkyl, etc.; R3 represents hydrogen or lower alkyl; and Q represents lower alkylene.)

  一种由以下通式[1]代表的新型含氮融合双环化合物或其药理学上可接受的盐。它们具有优异的 SK 通道阻断活性，可用作药物。[I]（式中，R0 代表氢、卤素等；R1 代表由式（a）或（b）表示的基团；A 代表由式（X）或（Y）表示的基团；D1、D2 和 D3 各自代表 N 或 CH；R2 代表卤素或任选卤化的低级烷基等；R3 代表氢或低级烷基；Q 代表低级亚烷基）。
• Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prohylaxis and treatment of disorders related thereto
  申请人：Arena Pharmaceuticals, Inc.

  公开号：EP2292620A2

  公开（公告）日：2011-03-09

  The present invention relates to certain fused aryl and heteroaryl derivatives of Formula (I) that are modulators of metabolism. Accordingly, compounds of the present invention are useful in the prophylaxis or treatment of metabolic disorders and complications thereof, such as, diabetes and obesity.

  本发明涉及某些可调节新陈代谢的式 (I) 融合芳基和杂芳基衍生物。 因此，本发明的化合物可用于预防或治疗代谢紊乱及其并发症，如糖尿病和肥胖症。