trans-stilbene-4,4'-disulfonyl chloride | 76700-68-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: trans-stilbene-4,4'-disulfonyl chloride
• 英文别名: stilbene-4,4'-disulfonyl chloride；4-[(E)-2-(4-chlorosulfonylphenyl)ethenyl]benzenesulfonyl chloride
• CAS: 76700-68-0
• 化学式: C₁₄H₁₀Cl₂O₄S₂
• 分子量: 377.269
• InChiKey: DQJXACCIXJKMKD-OWOJBTEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  85
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  trans-stilbene-4,4'-disulfonyl chloride 、 β-环糊精 在 吡啶 作用下， 反应 1.0h， 生成 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  Regiospecific A,C- and A,D-disulfonate capping of .beta.-cyclodextrin

  摘要：

  DOI：

  10.1021/ja00393a056
• 作为产物：
  描述：

  disodium trans-stilbene-4,4'-disulfonate 在 五氯化磷 作用下， 反应 2.0h， 生成 trans-stilbene-4,4'-disulfonyl chloride
  参考文献：
  名称：

  β-环糊精的区域特异性AC-和AD-二磺酸盐封端的表征。封盖作为一种高效的生产技术

  摘要：

  «coiffage» regioselectif de la β-cyclodextrine en utilisant une serie de dichlorures de sulfonylearomatiques steeles ClSO 2 ×SO 2 Cl (avec X=methylene-4,4' bis-benzo, oxy-4,4'双苯, 羰基-4,4' 双苯, 甲基-9 咔唑-3,6)

  DOI：

  10.1021/ja00330a039

文献信息

• A.C; A′.C′-doubly capped δ-cyclodextrin. Direct evidence for the capping structure
  作者：Iwao Tabushi、Lung Chi Yuan、Kazuhiro Shimokawa、Kan-ichi Yokota、Tadashi Mizutani、Yasuhisa Kuroda

  DOI：10.1016/s0040-4039(01)92908-9

  日期：——

  Doubly capped β-cyclodextrin was firstly prepared in good yield by the treatment of β- cyclodextrin with an excess amount (2.6/1 mol/mol) of benzophenone-3,3′-disulfonyl chloride. This successful double capping demonstrates that benzophenone-3,3′-disulfonyl capping takes place on A,C rings. The present double cap is a useful key intermediate for the preparation of regiospecifically tetrasubstituted

  首先通过用过量（2.6 / 1 mol / mol）二苯甲酮-3,3'-二磺酰氯处理β-环糊精以高收率制备双封端的β-环糊精。这种成功的双重封端证明了在A，C环上发生了二苯甲酮-3,3'-二磺酰基封端。本发明的双帽是用于制备区域特异性四取代的环糊精的有用的关键中间体。
• Viscoelastic collagen solution for ophthalmic use and method of preparation
  申请人：MINNESOTA MINING AND MANUFACTURING COMPANY

  公开号：EP0214853A2

  公开（公告）日：1987-03-18

  Native collagen is reacted with a di or tri-carboxylic acid halide, di or tri-sulfonyl halide, di or tri-anhydride, or di or tri-reactive active ester coupling agent to produce a chemically-modified collagen compound wherein one or more native collagen molecules are coupled at at least one lysine epsilon amino group by a discarbonyl, tricarbonyl, disulfonyl or tri- sulfonyl coupling group, or a coupling group having a plurality of moieties, at least two of which are carbonyl or sulfonyl groups. The reaction is done in a controlled manner so that the degree of cross-linking is limited. Any remaining lysine epsilon amino groups present in the coupled collagen product may be converted to carboxyamido or sulfonamido groups by acid halide, anhydride. sulfonyl halide or active ester amine-modifying agents. The resultant product when dissolved in a physiological buffer provides a viscoelastic solution having therapeutic application in a variety of surgical procedures, particularly in ophthalmic surgery. This viscoelastic solution "melts", i.e., exhibits a dramatic loss of viscosity, when subjected to temperatures of between 32 and 48°C.

  原生胶原与二或三羧酸卤化物、二或三磺酰卤化物、二或三酸酐或二或三反应活性酯偶联剂反应，生成化学修饰的胶原化合物，其中一个或多个原生胶原分子在至少一个赖氨酸ε氨基上通过二羰基、三羰基、二磺酰基或三磺酰基偶联基团，或具有多个分子的偶联基团，其中至少两个是羰基或磺酰基、三羰基、二磺酰基或三磺酰基偶联基团，或具有多个分子（其中至少两个是羰基或磺酰基）的偶联基团。反应以受控方式进行，因此交联程度有限。耦合胶原蛋白产品中剩余的赖氨酸ε氨基可通过酸卤化物、酸酐、磺酰卤化物或活性酯胺改性剂转化为羧酰胺基或磺酰胺基。由此产生的产品溶解在生理缓冲液中后，会形成一种粘弹性溶液，可用于各种外科手术，尤其是眼科手术。这种粘弹性溶液在 32 至 48°C 的温度下会 "融化"，即粘度急剧下降。
• Method of manufacturing modified particles and manufacturing device therefor
  申请人：Sharp Kabushiki Kaisha

  公开号：EP0916394A2

  公开（公告）日：1999-05-19

  Particles containing a monomer A are exposed to a super-saturated vapor of a monomer B which differs from and is polymerizable with monomer A, thereby condensing monomer B on the surface of the particles. Polymerization of monomer A and monomer B simply and rapidly produces spherical modified particles of uniform diameter.

  含有单体 A 的微粒暴露在单体 B 的过饱和蒸汽中，单体 B 与单体 A 不同并可聚合，从而在微粒表面凝结单体 B。单体 A 和单体 B 的聚合反应简单而迅速，可产生直径均匀的球形改性颗粒。
• Cyclodextrin based polymers, methods, compositions and applications thereof
  申请人：ATEN PORUS LIFESCIENCES

  公开号：US10869884B2

  公开（公告）日：2020-12-22

  The present disclosure relates to polymers comprising conjugates of cyclodextrin or derivatives thereof and a linker moiety, and their application in treating lipid storage disorders by the removal of lipids such as cholesterol from cells. The polymers having the following structure: Formula (I), wherein CD, L, and n are defined herein, exhibit improved properties including but not limited to improved biocompatibility, improved retention time, prolonged duration of action in cells, and increased efficacy in treating a variety of kidney diseases and associated conditions.

  本公开涉及由环糊精或其衍生物与连接分子的共轭物组成的聚合物，以及它们在通过从细胞中清除胆固醇等脂质来治疗脂质贮积症方面的应用。具有以下结构的聚合物：式 (I)，其中 CD、L 和 n 在此定义，具有改进的特性，包括但不限于改进的生物相容性、改进的保留时间、延长在细胞中的作用时间，以及提高治疗各种肾脏疾病和相关病症的功效。
• Biocleavable micelle compositions for use as drug carriers
  申请人：——

  公开号：US20010021703A1

  公开（公告）日：2001-09-13

  This invention discloses compositions and methods for preparing biocleavable or biodegradable micelle compositions for carrying and releasing drugs and other active agents for therapeutic or other medical uses. Methods are also disclosed for preparing biocleavable cyclodextrin micelle carriers that release drugs under controlled conditions. The invention also discloses biocleavable or biodegradable micelle compositions that are coupled to biorecognition molecules for targeting the delivery of drugs to their site of action.

  本发明公开了制备可生物裂解或可生物降解胶束组合物的组合物和方法，该组合物可携带和释放用于治疗或其他医疗用途的药物和其他活性剂。本发明还公开了制备可在受控条件下释放药物的可生物裂解环糊精胶束载体的方法。 本发明还公开了生物可裂解或生物可降解胶束组合物，这些组合物与生物识别分子耦合，用于将药物靶向输送到其作用部位。