| 1629670-53-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• CAS: 1629670-53-6
• 化学式: C₁₉H₁₉NO₇S₂
• 分子量: 437.494
• InChiKey: RNTTUTKAWREXNK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.24
• 重原子数：
  29.0
• 可旋转键数：
  3.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  134.81
• 氢给体数：
  2.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  在 甲烷磺酸 、 nitrosonium tetrafluoroborate 、 三乙胺 、 三氟乙酸 作用下， 以 水 、 乙腈 为溶剂， 反应 17.0h， 生成
  参考文献：
  名称：

  Azo-Sulforhodamine Dyes: A Novel Class of Broad Spectrum Dark Quenchers

  摘要：

  A rapid access to a novel class of water-soluble dark quencher dyes was achieved using an azo-coupling reaction between a fluorescent primary arylamine derived from a sulforhodamine 101 scaffold and a tertiary aniline equipped with different bioconjugatable groups. The thus obtained nonfluorescent azo-sulforhodamine hybrids display a broad quenching range spanning the visible to NIR regions. This was demonstrated through the preparation and enzymatic activation of FRET-based fluorogenic substrates of urokinase.

  DOI：

  10.1021/ol501753b
• 作为产物：
  描述：

  8-hydroxyjulolidine 、 disodium 2-formylbenzene-1,5-disulfonate 在 甲烷磺酸 作用下， 反应 0.25h， 生成
  参考文献：
  名称：

  Azo-Sulforhodamine Dyes: A Novel Class of Broad Spectrum Dark Quenchers

  摘要：

  A rapid access to a novel class of water-soluble dark quencher dyes was achieved using an azo-coupling reaction between a fluorescent primary arylamine derived from a sulforhodamine 101 scaffold and a tertiary aniline equipped with different bioconjugatable groups. The thus obtained nonfluorescent azo-sulforhodamine hybrids display a broad quenching range spanning the visible to NIR regions. This was demonstrated through the preparation and enzymatic activation of FRET-based fluorogenic substrates of urokinase.

  DOI：

  10.1021/ol501753b

文献信息

• Straightforward Access to Water-Soluble Unsymmetrical Sulfoxanthene Dyes: Application to the Preparation of Far-Red Fluorescent Dyes with Large Stokes’ Shifts
  作者：Arnaud Chevalier、Pierre-Yves Renard、Anthony Romieu

  DOI：10.1002/chem.201402306

  日期：2014.7.1

  efficient synthesis of water‐soluble unsymmetrical sulforhodamine/sulforhodol fluorophores containing a single julolidine fragment is presented. Owing to their valuable spectral properties in aqueous buffers, these dyes, especially those bearing a free aniline or phenol moiety, are valuable components of fluorogenic probes for a variety of biosensing applications. A further extension of this synthetic

  提出了一种有效的合成水溶性不对称磺基若丹明/磺胺甲酚荧光团的方法，该荧光团包含一个聚甲基吡啶核苷片段。由于它们在水性缓冲液中的宝贵光谱特性，这些染料，尤其是带有游离苯胺或苯酚部分的染料，是用于各种生物传感应用的荧光探针的重要组分。这种合成方法的进一步扩展到不寻常的苯酚，即7 - N，N-二烷基氨基-4-羟基香豆素，使我们能够提供具有远红外光谱特征的大斯托克斯位移的新型家族水溶性染料。