2-(1-benzothien-3-yl)-7-(2-naphthyl)-3-piperidin-4-yl-3H-imidazo[4,5-b]pyridine | 1127118-62-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-(1-benzothien-3-yl)-7-(2-naphthyl)-3-piperidin-4-yl-3H-imidazo[4,5-b]pyridine
• 英文别名: 2-(1-Benzothiophen-3-yl)-7-naphthalen-2-yl-3-piperidin-4-ylimidazo[4,5-b]pyridine
• CAS: 1127118-62-0
• 化学式: C₂₉H₂₄N₄S
• 分子量: 460.602
• InChiKey: DRIFFWACMFQMCA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  34
• 可旋转键数：
  3
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  71
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• IMIDAZOPYRIDINE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM
  申请人：Lundquist, IV Joseph Theodore

  公开号：US20090069319A1

  公开（公告）日：2009-03-12

  The present invention relates to imidazopyridine analogs, methods of making imidazopyridine analogs, compositions comprising an imidazopyridine analog, and methods for treating canonical Wnt-β-catenin cellular messaging system-related disorders comprising administering to a subject in need thereof an effective amount of an imidazopyridine analog.

  本发明涉及咪唑吡啶类似物，制备咪唑吡啶类似物的方法，包含咪唑吡啶类似物的组合物，以及治疗经典Wnt-β-catenin细胞信使系统相关疾病的方法，包括向需要的受试者施用有效量的咪唑吡啶类似物。
• [EN] PREPARATION OF SYNTHETIC NUCLEOSIDES VIA p-ALLYL TRANSITION METAL COMPLEX FORMATION<br/>[FR] PRÉPARATION DE NUCLÉOSIDES DE SYNTHÈSE AU MOYEN DE LA FORMATION DE COMPLEXES MÉTALLIQUES DE TRANSITION ?-ALLYLIQUES
  申请人：UNIV EMORY

  公开号：WO2009021114A1

  公开（公告）日：2009-02-12

  This invention provides highly regioselective and stereoselective processes for preparing synthetic nucleosides. A process for the preparation of synthetic nucleosides is provided that comprises a) preparing a bicycloamide derivative, b) reacting the bicycloamide derivative with a nucleic acid base or heterocyclic base or salt thereof in the presence of a transition metal catalyst to form a cyclopentenecarboxamide, and c) cleaving a carboxamide group from the cyclopentenecarboxamide to form the synthetic nucleoside. The processes according to the invention can be used for the synthesis of a variety of anti-viral agents, including Abacavir, Carbovir, and Entecavir, as well as derivatives thereof.

  这项发明提供了用于制备合成核苷的高度区域选择性和立体选择性的过程。提供了一种用于制备合成核苷的过程，包括a)制备双环酰胺衍生物，b)将双环酰胺衍生物与核酸碱基或杂环碱基或其盐在过渡金属催化剂存在下反应，形成环戊烯羧酰胺，c)从环戊烯羧酰胺中裂解羧酰胺基团以形成合成核苷。根据该发明的过程可用于合成各种抗病毒药物，包括阿巴卡韦、卡波韦和恩替卡韦，以及其衍生物。
• PREPARATION OF SYNTHETIC NUCLEOSIDES VIA pi-ALLYL TRANSITION METAL COMPLEX FORMATION
  申请人：Emory University

  公开号：EP2185508A1

  公开（公告）日：2010-05-19
• [EN] IMIDAZOPYRIDINE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM<br/>[FR] ANALOGUES DE L'IMIDAZOPYRIDINE ET LEUR UTILISATION EN TANT QU'AGONISTES DU SYSTÈME DE MESSAGERIE CELLULAIRE WNT-BÊTA-CATÉNINE
  申请人：WYETH CORP

  公开号：WO2009029609A1

  公开（公告）日：2009-03-05

  The present invention relates to imidazopyridine analogs, methods of making imidazopyridine analogs, compositions comprising an imidazopyridine analog, and methods for treating canonical Wnt-ß-catenin cellular messaging system-related disorders comprising administering to a subject in need thereof an effective amount of an imidazopyridine analog.