2-(tert-butoxy)-2-(9-cyclopropyl-2-methyl-4-(5-methylchroman-6-yl)-6,7,8,9-tetrahydro-5H-pyrido[2,3-b]indol-3-yl)acetic acid | 1418716-95-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 2-(tert-butoxy)-2-(9-cyclopropyl-2-methyl-4-(5-methylchroman-6-yl)-6,7,8,9-tetrahydro-5H-pyrido[2,3-b]indol-3-yl)acetic acid
• 英文别名: 2-Tert-butoxy-2-[9-cyclopropyl-2-methyl-4-(5-methylchroman-6-yl)-5,6,7,8-tetrahydropyrido[2,3-b]indol-3-yl]acetic acid；2-[9-cyclopropyl-2-methyl-4-(5-methyl-3,4-dihydro-2H-chromen-6-yl)-5,6,7,8-tetrahydropyrido[2,3-b]indol-3-yl]-2-[(2-methylpropan-2-yl)oxy]acetic acid
• CAS: 1418716-95-6
• 化学式: C₃₁H₃₈N₂O₄
• 分子量: 502.654
• InChiKey: HLTWXSBILIMONU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  37
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  73.6
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] AZAINDOLE COMPOUNDS AND METHODS FOR TREATING HIV<br/>[FR] COMPOSÉS D'AZA-INDOLE ET PROCÉDÉS POUR TRAITER LE VIH
  申请人：GLAXOSMITHKLINE LLC

  公开号：WO2013012649A1

  公开（公告）日：2013-01-24

  Provided are compounds and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and their use for treating viral infections mediated by a member of the retrovirus family of viruses such as the Human Immunodeficiency Virus (HIV).

  提供的是化合物及其药用盐，它们的药物组合物，它们的制备方法，以及它们用于治疗由逆转录病毒家族成员介导的病毒感染，如人类免疫缺陷病毒（HIV）的用途。
• Azaindole Compounds and Methods for Treating HIV
  申请人：De La Rosa Martha Alicia

  公开号：US20130018049A1

  公开（公告）日：2013-01-17

  Provided are compounds and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and their use for treating viral infections mediated by a member of the retrovirus family of viruses such as the Human Immunodeficiency Virus (HIV).

  提供的是化合物及其药学上可接受的盐，它们的药物组合物，它们的制备方法以及它们用于治疗由反转录病毒家族的病毒介导的病毒感染，如人类免疫缺陷病毒（HIV）的用途。
• AZAINDOLE COMPOUNDS AND METHODS FOR TREATING HIV
  申请人：VIIV Healthcare UK Limited

  公开号：EP2731436A1

  公开（公告）日：2014-05-21
• US8609653B2
  申请人：——

  公开号：US8609653B2

  公开（公告）日：2013-12-17