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phenyl(9,12,18,20-tetrazapentacyclo[11.7.0.02,10.03,8.014,19]icosa-1(13),2(10),3,5,7,14(19),15,17-octaen-12-yl)methanone | 120061-56-5

中文名称
——
中文别名
——
英文名称
phenyl(9,12,18,20-tetrazapentacyclo[11.7.0.02,10.03,8.014,19]icosa-1(13),2(10),3,5,7,14(19),15,17-octaen-12-yl)methanone
英文别名
——
phenyl(9,12,18,20-tetrazapentacyclo[11.7.0.02,10.03,8.014,19]icosa-1(13),2(10),3,5,7,14(19),15,17-octaen-12-yl)methanone化学式
CAS
120061-56-5
化学式
C23H16N4O
mdl
——
分子量
364.406
InChiKey
KCROGMIWMZUZIH-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    4.87
  • 重原子数:
    28.0
  • 可旋转键数:
    1.0
  • 环数:
    6.0
  • sp3杂化的碳原子比例:
    0.04
  • 拓扑面积:
    64.78
  • 氢给体数:
    2.0
  • 氢受体数:
    2.0

反应信息

  • 作为反应物:
    参考文献:
    名称:
    Molecular yardsticks. Rigid probes to define the spatial dimensions of the benzodiazepine receptor binding site
    摘要:
    A series of rigid planar azadiindoles (8a, 8b, and 8d), benzannelated pyridodiindoles (11a, 11b, and 11d), and indolopyridoimidazoles (11c, 20, and 24) were synthesized from 4-oxo-1,2,3,4-tetrahydro-beta-carboline 5 via the Fischer indole cyclization with the appropriate arylhydrazines. These analogues were employed as probes ("molecular yardsticks") to define the spatial dimensions of the lipophilic regions of the benzodiazepine receptor (BzR) binding cleft. Benzannelated indoles 11a-d and indolopyridoimidazoles 20 and 24 were important in establishing an area of negative interaction (S1, see Figure 6, part b) in the binding cleft common to the interactions of both inverse agonists and agonists. Data from this chemical and computer-assisted analysis of the pharmacophore (see Figure 6) indicates that inverse agonists and agonists bind to the same binding region, but the pharmacophoric descriptors required for the two activities are different, in keeping with previous studies with these planar ligands. However, the hydrogen bond donating site H-1 and the lipophilic region L1 in the receptor binding site are common interactions experienced by both series of ligands. The low affinities of both indolo[3,2-c]carbazole (3a) and indolo[3,2-b]isoquinoline (3b) for the BzR are consonant with the requirements of a hydrogen bond acceptor interaction at donor site H-1 and a hydrogen bond donor interaction at acceptor site A2 for potent inverse agonist activity in the beta-carboline series. The hydrochloride salts of 1-aza- 8a (IC50 10.6 nM), 2-aza- 8b (IC50 51.5 nM), and 4-azadiindole 8d (IC50 11.2 nM) were found to be much more soluble in water than the corresponding salt of the parent diindole 2. Moreover, aza analogues 8a and 8b were shown to be partial inverse agonists with proconvulsant potencies comparable to that of the parent diindole 2.
    DOI:
    10.1021/jm00100a017
  • 作为产物:
    参考文献:
    名称:
    Tan, Yun-chou; Trudell, Mark L.; Cook, James M., Heterocycles, 1988, vol. 27, # 7, p. 1607 - 1614
    摘要:
    DOI:
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文献信息

  • TAN, YUN-CHOU;TRUDELL, MARK L.;COOK, JAMES M., HETEROCYCLES, 27,(1988) N, C. 1607-1614
    作者:TAN, YUN-CHOU、TRUDELL, MARK L.、COOK, JAMES M.
    DOI:——
    日期:——
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同类化合物

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