(1-Piperidin-4-ylpiperidin-2-yl)methanol | 340962-70-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (1-Piperidin-4-ylpiperidin-2-yl)methanol
• 英文别名: (1-piperidin-4-ylpiperidin-2-yl)methanol
• CAS: 340962-70-1
• 化学式: C₁₁H₂₂N₂O
• 分子量: 198.308
• InChiKey: RJHGJWAQICZARS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  35.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-3-(3,4-dichlorophenyl)-5-formyl-2(Z)-pentanone O-methyl-oxime 、 (1-Piperidin-4-ylpiperidin-2-yl)methanol 在 2,2,2-三氟乙醇 、 3 A molecular sieve 、 sodium cyanoborohydride 作用下， 生成 [1-[1-[(4Z)-5-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-3-(3,4-dichlorophenyl)-4-methoxyiminopentyl]piperidin-4-yl]piperidin-2-yl]methanol
  参考文献：
  名称：

  Synthesis of substituted 4(Z)-(methoxyimino)pentyl-1-piperidines as dual NK1/NK2 inhibitors

  摘要：

  The NK1 and NK2 receptor activity of a series of 5-[(3,5-bis(trifluoromethyl)phenyl)methoxy]-3-(3,4-dichlorophenyl)4(Z)-(methoxyimino)pentyl-1-piperidines was evaluated. Compounds 11d, 11e, 11f, 12a, and 12k were found to be our most potent inhibitors. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00702-2
• 作为产物：
  描述：

  2-哌啶甲醇 在 palladium on activated charcoal 2,2,2-三氟乙醇 、 3 A molecular sieve 、 氢气 、 sodium cyanoborohydride 作用下， 以 甲醇 为溶剂， 生成 (1-Piperidin-4-ylpiperidin-2-yl)methanol
  参考文献：
  名称：

  Synthesis of substituted 4(Z)-(methoxyimino)pentyl-1-piperidines as dual NK1/NK2 inhibitors

  摘要：

  The NK1 and NK2 receptor activity of a series of 5-[(3,5-bis(trifluoromethyl)phenyl)methoxy]-3-(3,4-dichlorophenyl)4(Z)-(methoxyimino)pentyl-1-piperidines was evaluated. Compounds 11d, 11e, 11f, 12a, and 12k were found to be our most potent inhibitors. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00702-2

文献信息

• Synthesis of substituted 4(Z)-(methoxyimino)pentyl-1-piperidines as dual NK1/NK2 inhibitors
  作者：Pauline C Ting、Joe F Lee、John C Anthes、Neng-Yang Shih、John J Piwinski

  DOI：10.1016/s0960-894x(00)00702-2

  日期：2001.2

  The NK1 and NK2 receptor activity of a series of 5-[(3,5-bis(trifluoromethyl)phenyl)methoxy]-3-(3,4-dichlorophenyl)4(Z)-(methoxyimino)pentyl-1-piperidines was evaluated. Compounds 11d, 11e, 11f, 12a, and 12k were found to be our most potent inhibitors. (C) 2001 Elsevier Science Ltd. All rights reserved.