phenyl (4-(4-chlorophenyl)piperazin-1-yl)phosphonochloridate | 1241392-56-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: phenyl (4-(4-chlorophenyl)piperazin-1-yl)phosphonochloridate
• CAS: 1241392-56-2
• 化学式: C₁₆H₁₇Cl₂N₂O₂P
• 分子量: 371.203
• InChiKey: HSVNEZPDBKBKOJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.89
• 重原子数：
  23.0
• 可旋转键数：
  4.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  32.78
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  2-(4-chlorophenyl)-5,7-dimethoxyquinolin-4-ol 、 phenyl (4-(4-chlorophenyl)piperazin-1-yl)phosphonochloridate 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 以32%的产率得到2-(4-chlorophenyl)-5,7-dimethoxyquinolin-4-yl phenyl (4-(4-chlorophenyl)piperazin-1-yl)phosphonate
  参考文献：
  名称：

  Synthesis of Novel Piperazine Phosphoramidate Analogues of 2-Arylquinolones

  摘要：

  A series of novel piperazine phosphoramidate derivatives of 2-arylquinolones were synthesized to improve their physicochemical and biological properties through a facile phosphorylating reaction. Their structures were elucidated by NMR, ESI MS, and HRMS.

  DOI：

  10.1080/10426500903120750
• 作为产物：
  描述：

  1-(4-氯苯基)哌嗪 、 二氯磷酸苯酯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 phenyl (4-(4-chlorophenyl)piperazin-1-yl)phosphonochloridate
  参考文献：
  名称：

  Synthesis of Novel Piperazine Phosphoramidate Analogues of 2-Arylquinolones

  摘要：

  A series of novel piperazine phosphoramidate derivatives of 2-arylquinolones were synthesized to improve their physicochemical and biological properties through a facile phosphorylating reaction. Their structures were elucidated by NMR, ESI MS, and HRMS.

  DOI：

  10.1080/10426500903120750

文献信息

• Synthesis and Spectroscopic Characterization of Some New Piperazine Phosphoramide Derivatives of 4-Hydroxycoumarin
  作者：Xiaolan Chen、Jinwei Yuan、Lingbo Qu、Zhibo Qu、Shaohua Xu、Fujun Wang、Yufen Zhao

  DOI：10.1080/10426507.2011.597799

  日期：2012.2.1

  Abstract A series of new piperazine phosphoramide derivatives of 4-hydroxycoumarin were synthesized through a facile phosphorylating reaction starting from 4-hydroxycoumarin and various phosphorylating agents. The title compounds were characterized by IR, NMR, electrospray ionization-mass spectrometry, and high-resolution mass spectrometry, and their spectroscopic data were further analyzed to feature

  摘要 以4-羟基香豆素和多种磷酸化剂为原料，通过简便的磷酸化反应合成了一系列新型4-羟基香豆素哌嗪磷酰胺衍生物。标题化合物通过IR、NMR、电喷雾电离-质谱和高分辨质谱进行表征，并进一步分析它们的光谱数据以表征该类化合物的相关光谱特征。图形概要
• Synthesis and Characterization of Phosphoramide Piperazine Analogs of Paeonol
  作者：Xu Li、Xiaolan Chen、Jinwei Yuan、Lingbo Qu、Haisheng Zhu、Wenzhu Bi、Yufen Zhao

  DOI：10.1080/10426507.2014.965822

  日期：2015.4.3

  Based on the phosphorylated reaction, an efficient general synthetic approach that provide facile, rapid and cheap access to a wide range of novel phosphoramide derivatives of paeonol has been developed. These analogues of paeonol are synthesized in high yields and elucidated by IR, HR MS, and NMR.