4-(4-ethanesulfonyl-phenyl)-1-hydroxy-naphthalene-2-carboxylic acid | 914775-15-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-(4-ethanesulfonyl-phenyl)-1-hydroxy-naphthalene-2-carboxylic acid
• 英文别名: 4-(4-Ethylsulfonylphenyl)-1-hydroxynaphthalene-2-carboxylic acid
• CAS: 914775-15-8
• 化学式: C₁₉H₁₆O₅S
• 分子量: 356.399
• InChiKey: ZPQHHZRKSIWLBY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  100
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• HALOALKYLSULFONE SUBSTITUTED COMPOUNDS USEFUL FOR TREATING OBESITY AND DIABETES
  申请人：Olesen Preben Houlberg

  公开号：US20100041657A1

  公开（公告）日：2010-02-18

  The present invention relates to compounds of formula I, in which at least one of R5, R6 and R7 is SR12, S(O)R12 or S(O)2R12 group where R12 is a C1-6haloalkyl group, that act, as chemical uncouplers. Compounds of the invention are useful in the treatment, including prevention, of obesity, diabetes and a number of diseases or conditions associated therewith.

  本发明涉及公式I的化合物，其中R5，R6和R7中至少有一个是SR12，S（O）R12或S（O）2R12基团，其中R12是C1-6卤代烷基基团，可作为化学解偶联剂。本发明的化合物在治疗，包括预防肥胖症，糖尿病以及与之相关的许多疾病或病况方面非常有用。
• NEW HALOALKYLSULFONE SUBSTITUTED COMPOUNDS USEFUL FOR TREATING OBESITY AND DIABETES
  申请人：NOVO NORDISK A/S

  公开号：EP1881961A1

  公开（公告）日：2008-01-30
• [EN] NEW HALOALKYLSULFONE SUBSTITUTED COMPOUNDS USEFUL FOR TREATING OBESITY AND DIABETES<br/>[FR] NOUVEAUX COMPOSES D'HALOALKYLSULFONE SUBSTITUES UTILES DANS LE TRAITEMENT DE L'OBESITE ET DE DIABETES
  申请人：NOVO NORDISK AS

  公开号：WO2006120178A1

  公开（公告）日：2006-11-16

  [EN] The present invention relates to compounds of formula I, in which at least one of R5, R6 and R7 is SR12, S(O)R12 or S(O)2R12 group where R12 is a C1-6haloalkyl group, that act, as chemical uncouplers. Compounds of the invention are useful in the treatment, including prevention, of obesity, diabetes and a number of diseases or conditions associated therewith.
  [FR] L'invention concerne des composés de formule (I) dans laquelle R5, R6 ou R7 représentent le groupe SR12, S(O)R12 ou S(O)2R12 et où R12 représente un groupe C1-6haloalkyle, lesdits composés agissant en tant que découpleurs chimiques. Les composés selon l'invention sont utiles dans le traitement, y compris dans la prévention de l'obésité, de diabètes et d un nombre de maladies ou d'états associés.