| 1107650-95-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• CAS: 1107650-95-2
• 化学式: C₂₉H₃₃N₃O₄
• 分子量: 487.599
• InChiKey: ULSCAIHXDBRTSM-RUZDIDTESA-N

反应信息

• 作为反应物：
  描述：

  在 sodium hydroxide 、 水 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 以60%的产率得到4-[[(R)-2-[[methyl[2-oxo-2-[(4-phenoxyphenyl)amino]ethyl]amino]methyl]-1-pyrrolidinyl]methyl]benzoic acid
  参考文献：
  名称：

  Synthesis of N-alkyl glycine amides as potent inhibitors of leukotriene A4 hydrolase

  摘要：

  The synthesis and biological evaluation of a series of N-alkyl glycine amide analogs as LTA(4)-h inhibitors and the importance of the introduction of a benzoic acid group to the potency and pharmacokinetic parameters of our analogs are described. The lead compound in the series, 4q, has excellent potency and oral bioavailability. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.06.046
• 作为产物：
  描述：

  4-溴甲基苯甲酸甲酯 、 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以40%的产率得到
  参考文献：
  名称：

  Synthesis of N-alkyl glycine amides as potent inhibitors of leukotriene A4 hydrolase

  摘要：

  The synthesis and biological evaluation of a series of N-alkyl glycine amide analogs as LTA(4)-h inhibitors and the importance of the introduction of a benzoic acid group to the potency and pharmacokinetic parameters of our analogs are described. The lead compound in the series, 4q, has excellent potency and oral bioavailability. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.06.046