3,3-Difluoro-3-phenylpropanoic acid | 1507967-83-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: 3,3-Difluoro-3-phenylpropanoic acid
• CAS: 1507967-83-0
• 化学式: C₉H₈F₂O₂
• 分子量: 186.15
• InChiKey: RQWQHUMEKKWWMN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] COMPOUNDS USEFUL IN HIV THERAPY<br/>[FR] COMPOSÉS UTILES DANS LA THÉRAPIE DU VIH
  申请人：VIIV HEALTHCARE CO

  公开号：WO2021194828A1

  公开（公告）日：2021-09-30

  The invention relates to compounds of Formula (I), salts thereof, pharmaceutical compositions thereof, as well as methods of treating or preventing HIV in subjects.

  这项发明涉及公式（I）的化合物，其盐，药物组合物，以及治疗或预防HIV的方法。
• PEPTIDE BORONIC ACID INHIBITORS OF HEPATITIS C VIRUS PROTEASE
  申请人：Bristol-Myers Squibb Pharma Company

  公开号：EP1196436A2

  公开（公告）日：2002-04-17
• INHIBITORS OF HEPATITIS C VIRUS NS3 PROTEASE
  申请人：Bristol-Myers Squibb Pharma Company

  公开号：EP1261611A2

  公开（公告）日：2002-12-04
• US6972296B2
  申请人：——

  公开号：US6972296B2

  公开（公告）日：2005-12-06
• [EN] PEPTIDE BORONIC ACID INHIBITORS OF HEPATITIS C VIRUS PROTEASE<br/>[FR] INHIBITEURS DE LA PROTEASE DU VIRUS DE L'HEPATITE C A BASE D'ACIDE BORONIQUE PEPTIDE
  申请人：DU PONT PHARM CO

  公开号：WO2001002424A2

  公开（公告）日：2001-01-11

  The present invention relates generally to novel α-aminoboronic acids and corresponding peptide analogs represented by structural Formula (I) or pharmaceutically acceptable salt forms thereof, wherein R?1, R2, R3, Y1, Y2¿, and A are described herein. The invention is also concerned with pharmaceutical formulations comprising these novel compounds as active ingredients and the use of the novel compounds and their formulations in the treatment of hepatitis C viral infections. The compounds of the invention are inhibitors of hepatitis C viral protease.