2-(pyrazin-2-yl)naphthoimidazole | 850706-24-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-(pyrazin-2-yl)naphthoimidazole
• 英文别名: PZNI；2-pyrazin-2-yl-1H-benzo[f]benzimidazole
• CAS: 850706-24-0
• 化学式: C₁₅H₁₀N₄
• 分子量: 246.271
• InChiKey: VRSKARZJIRGQSS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  cis-dichlorobis(1,10-phenanthroline)ruthenium(II) dihydrate 、 2-(pyrazin-2-yl)naphthoimidazole 、 sodium perchlorate 以 乙二醇 为溶剂， 以64%的产率得到[Ru(1,10-phenanthroline)2(2-(pyrazin-2-yl)naphthoimidazole)](ClO4)2
  参考文献：
  名称：

  Ruthenium(II) complexes containing asymmetric 2-(pyrazin-2-yl)naphthoimidazole: syntheses, characterization, DNA-binding and photocleavage studies

  摘要：

  A novel asymmetric bidentate ligand, 2-(pyrazin-2-yl)naphthoimidazole (PZNI), and its Ru(II) complexes [Ru(bPY)(2)(PZNI)](2+) (1) and [Ru(phen)2(PZNI)]21 (2) have been synthesized and characterized by elemental analysis, mass spectra, H-1 NMR, and electronic spectroscopy. The electrochemical behaviors of the novel complexes were studied by cyclic voltammetry. The DNA-binding properties of the complexes were investigated by spectroscopic methods and viscosity measurements. The experimental results indicate that the complexes 1 and 2 interact with calf thymus DNA by intercalative mode via the terminal naphthyl ring into the base pairs of DNA. The two Ru(11) complexes have also been found to promote the cleavage of plasmid pBR 322 DNA from the supercoiled form I to the open circular form II upon irradiation. (c) 2005 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2004.12.037