Anhydrotetracyclin | 1665-56-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 四环素类
• 英文名称: Anhydrotetracyclin
• 英文别名: 5a.6-Anhydro-tetracyclin；4-(dimethylamino)-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-4a,5-dihydro-4H-tetracene-2-carboxamide
• CAS: 1665-56-1；7518-17-4
• 化学式: C₂₂H₂₂N₂O₇
• 分子量: 426.426
• InChiKey: CXCVEERYMJZMMM-UHFFFAOYSA-N

物化性质

• 熔点：
  221-222 °C (decomp)(Solv: ethyl acetate (141-78-6))
• 沸点：
  708.6±60.0 °C(Predicted)
• 密度：
  1.60±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.46
• 重原子数：
  31.0
• 可旋转键数：
  2.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  161.39
• 氢给体数：
  5.0
• 氢受体数：
  8.0

文献信息

• Isolation of tetracycline derivatives
  申请人：Tsiperman Evgeny

  公开号：US20070244335A1

  公开（公告）日：2007-10-18

  Provided is a process for the isolation of tetracycline derivatives.

  提供一种分离四环素衍生物的过程。
• Methods of regulating expression of genes or of gene products using substituted tetracycline compounds
  申请人：Paratek Pharmaceuticals, Inc.

  公开号：EP2218785A2

  公开（公告）日：2010-08-18

  The invention relates to methods of regulating expression of genes or of gene products using substituted tetracycline derivatives.

  本发明涉及使用取代的四环素衍生物调节基因或基因产物表达的方法。
• Amino-methyl substituted tetracycline compounds
  申请人：Paratek Pharmaceuticals, Inc.

  公开号：EP2301534A1

  公开（公告）日：2011-03-30

  1. A tetracycline compound having the following formula: wherein: J5 and J6 are each independently hydrogen, alkyl, alkenyl, alkynyl, aryl, sulfonyl, acyl, substituted carbonyl or substituted thiocarbonyl, or linked to form a ring; J7 and J8 are each alkyl, halogen, or hydrogen; and R7 is hydrogen, or pharmaceutically acceptable salts thereof.

  1.具有下式的四环素化合物： 其中 J5和J6各自独立地是氢、烷基、烯基、炔基、芳基、磺酰基、酰基、取代的羰基或取代的硫代羰基，或连接成环； J7 和 J8 分别是烷基、卤素或氢；以及 R7 为氢、 或其药学上可接受的盐。
• SUBSTITUTED TETRACYCLINE COMPOUNDS FOR TREATMENT OF INFLAMMATORY SKIN DISORDERS
  申请人：Paratek Pharmaceuticals, Inc.

  公开号：EP3488853A1

  公开（公告）日：2019-05-29

  Methods and compositions for the treatment of skin disorders (e.g., acne, rosacea) are described.

  描述了治疗皮肤疾病（如痤疮、酒渣鼻）的方法和组合物。
• Multi-subunit biological complexes for treatment of plaque-associated diseases
  申请人：Madasamy Shanmugavel

  公开号：US20090104121A1

  公开（公告）日：2009-04-23

  Provided herein are methods and compositions for the in vitro formation of multi subunit biological platforms. The biological platforms may be used to screen chemical or biological compounds, in particular compounds that may disrupt or otherwise affect the formation of the multi subunit complexes, or disrupt already-formed in vitro assembled multi subunit complexes. Also provided herein are methods and compositions for the in vivo formation of multi-subunit biological complexes. The methods and compositions described herein may be used to develop animal models of diseases or disorders.