6-[[4-[(5,7-Dihydroxy-2-methyl-4-oxochromen-6-yl)methylideneamino]phenyl]iminomethyl]-5,7-dihydroxy-2-methylchromen-4-one | 1377148-74-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 6-[[4-[(5,7-Dihydroxy-2-methyl-4-oxochromen-6-yl)methylideneamino]phenyl]iminomethyl]-5,7-dihydroxy-2-methylchromen-4-one
• CAS: 1377148-74-7
• 化学式: C₂₈H₂₀N₂O₈
• 分子量: 512.475
• InChiKey: PKEAASCQBBVPIA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  38
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  158
• 氢给体数：
  4
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  cobalt(II) diacetate tetrahydrate 、 6-[[4-[(5,7-Dihydroxy-2-methyl-4-oxochromen-6-yl)methylideneamino]phenyl]iminomethyl]-5,7-dihydroxy-2-methylchromen-4-one 以 乙醇 为溶剂， 生成
  参考文献：
  名称：

  Spectroscopic and biological activities studies of bivalent transition metal complexes of Schiff bases derived from condensation of 1,4-phenylenediamine and benzopyrone derivatives

  摘要：

  Many tools of analysis such as elemental analyses, infrared, ultraviolet-visible, electron spin resonance (ESR) and thermal analysis, as well as conductivity and magnetic susceptibility measurements were used to elucidate the structures of the newly prepared Co(II), Ni(II) and Cu(II) complexes with Schiff bases derived from the condensation of 1,4-phenylenediamine with 6-formyl-7-hydroxy-5-methoxy-2-methylbenzo-pyran-4-one (H2L) or 5,7-dihydroxy-6-formyl-2-methylbenzopyran-4-one (H4L). The data showed that all formed complexes are 1:1 or 2:2 (M:L) and non-electrolyte chelates. The Co(II) and Cu(II) complexes of the two Schiff bases were screened for antibacterial activities by the disk diffusion method. The antibacterial activity was screened using Escherichia coli and Staphylococcus capitis but the antifungal activity was examined by using Aspergillus flavus and Candida albicans. The Results showed that the tested complexes have antibacterial, except Cu-H4L, but not antifungal activities. (C) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2013.08.037
• 作为产物：
  描述：

  7-羟基-5-甲氧基-2-甲基-4-氧代-4H-1-苯并吡喃-6-甲醛 在 盐酸 、 水 作用下， 以 乙醇 为溶剂， 反应 1.5h， 生成 6-[[4-[(5,7-Dihydroxy-2-methyl-4-oxochromen-6-yl)methylideneamino]phenyl]iminomethyl]-5,7-dihydroxy-2-methylchromen-4-one
  参考文献：
  名称：

  Microplate assay for screening the antibacterial activity of Schiff bases derived from substituted benzopyran-4-one

  摘要：

  Schiff bases (SB1-SB3) were synthesized from the condensation of 6-formyl-7-hydroxy-5-methoxy2-methylbenzopyran-4-one with 2-aminopyridine (SB1), p-phenylenediamine (SB2) and o-phenylenediamine (SB3), while Schiff bases (SB4-SB6) were synthesized by condensation of 5,7-dihydroxy-6-formyl-2-methylbenzopyran-4-one with 2-aminopyridine (SB4), p-phenylenediamine (SB5) and o-phenylenediamine (SB6). Schiff bases were characterized using elemental analysis, IR, UV-Vis, H-1 NMR, C-13 NMR and mass spectroscopy. These compounds were screened for antibacterial activities by micro-plate assay technique. Escherichia coli and Staphylococcus capitis were exposed to different concentrations of the Schiff bases. Results showed that the antibacterial effect of these Schiff bases on Gram-negative bacteria were higher than that on Gram-positive bacteria moreover, the Schiff bases containing substituent OCH3 on position five have higher antibacterial activity than that containing hydroxy group on the same position, (C) 2012 Elsevier By. All rights reserved.

  DOI：

  10.1016/j.saa.2012.04.042