8-methyl-5-phenyl-6,7,8,9-tetrahydro-1H-pyrrolo-[3,2-h]-isoquinoline-2,3-dione-3-acetyloxim | 178936-65-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: 8-methyl-5-phenyl-6,7,8,9-tetrahydro-1H-pyrrolo-[3,2-h]-isoquinoline-2,3-dione-3-acetyloxim
• 英文别名: 8-methyl-5-phenyl-6,7,8,9-tetrahydro-1H-pyrrolo[3,2-h]isoquinoline-2,3-dione-3-O-acetyloxime；8-Methyl-5-phenyl-6,7,8,9-tetrahydro-1H-pyrrolo[3,2-h]isoquinoline-2,3-dione-3-acetyloxime；[(8-Methyl-2-oxo-5-phenyl-1,6,7,9-tetrahydropyrrolo[3,2-h]isoquinolin-3-ylidene)amino] acetate
• CAS: 178936-65-7
• 化学式: C₂₀H₁₉N₃O₃
• 分子量: 349.389
• InChiKey: ZSWZIVHYXPMAGB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  71
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Isatine derivatives with neurotrophic activity
  申请人：——

  公开号：US20030040518A1

  公开（公告）日：2003-02-27

  The present invention relates to novel isatin derivatives, pharmaceutical compositions comprising the isatin derivatives of the invention, methods of preparing the isatin derivatives of the invention, their use in the treatment of neurodegenerative diseases and for the regeneration or prevention of degeneration of lesioned and damaged neurons, and methods of treatment of neurodegenerative diseases and for the regeneration or prevention of degeneration of lesioned and damaged neurons.

  本发明涉及新型吲哚酮衍生物，包括本发明的吲哚酮衍生物的药物组合物，制备本发明的吲哚酮衍生物的方法，它们在治疗神经退行性疾病以及在再生或预防受损和受损神经元的退化中的用途，以及治疗神经退行性疾病以及再生或预防受损和受损神经元的方法。
• [EN] ISATINE DERIVATIVES WITH NEUROTROPHIC ACTIVITY<br/>[FR] DERIVES DE L'ISATINE A ACTIVITE NEUROTROPHIQUE
  申请人：NEUROSEARCH AS

  公开号：WO2001055110A1

  公开（公告）日：2001-08-02

  The present invention relates to novel isatin derivatives, pharmaceutical compositions comprising the isatin derivatives of the invention, methods of preparing the isatin derivatives of the invention, their use in the treatment of neurodegenerative diseases and for the regeneration or prevention of degeneration of lesioned and damaged neurons, and methods of treatment of neurodegenerative diseases and for the regeneration or prevention of degeneration of lesioned and damaged neurons.

  本发明涉及新型异喹啉衍生物，包括本发明的异喹啉衍生物的制药组合物，制备本发明的异喹啉衍生物的方法，它们在治疗神经退行性疾病和再生或预防损伤和受损神经元的退化中的使用，以及神经退行性疾病的治疗和再生或预防受损神经元的退化的方法。
• Inhibitors of proton-gated cation channels and their use in the treatment of ischaemic disorders
  申请人：——

  公开号：US20020058663A1

  公开（公告）日：2002-05-16

  This invention relates to the use of compounds capable of inhibiting the activity of a proton-gated cation channel in the treatment or aleviation of diseases or disorders associated with, or mediated by a drop in extracellular pH.

  本发明涉及使用能够抑制质子门控阳离子通道活性的化合物来治疗或缓解与细胞外pH下降相关或介导的疾病或障碍。
• Isatin derivatives with neurotrophic activity useful in the treatment of diseases mediated by the nerve growth factor (NGF) activation
  申请人：NEUROSEARCH A/S

  公开号：EP1736468A2

  公开（公告）日：2006-12-27

  The present invention relates to novel isatin derivatives of formula (I), pharmaceutical compositions comprising the isatin derivatives of the invention, methods of preparing the isatin derivatives of the invention and their use in the treatment of neurodegenerative diseases and for the regeneration or prevention of degeneration of lesioned and damaged neurons wherein, A represents a group of the formula -C(NOR2)- or -NR2-CO-;

  本发明涉及式(I)的新型异汀衍生物、包含本发明异汀衍生物的药物组合物、制备本发明异汀衍生物的方法及其在治疗神经退行性疾病和再生或预防病变和受损神经元变性中的用途。 其中 A 代表式 -C(NOR2)- 或 -NR2-CO- 的基团；
• INDOLE-2,3-DIONE-3-OXIME DERIVATIVES, THEIR PREPARATION AND USE
  申请人：NEUROSEARCH A/S

  公开号：EP0781284B1

  公开（公告）日：2000-01-12