dimethyl ((2S,2'S)-((2S,2'S)-2,2'-(5,5'-(6,11-dihydrotribenzo[b,d,h][1,6]dioxecine-3,14-diyl)bis(1H-imidazole-5,2-diyl))bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane-2,1-diyl))dicarbamate | 1449762-38-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并吡喃类
• 英文名称: dimethyl ((2S,2'S)-((2S,2'S)-2,2'-(5,5'-(6,11-dihydrotribenzo[b,d,h][1,6]dioxecine-3,14-diyl)bis(1H-imidazole-5,2-diyl))bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane-2,1-diyl))dicarbamate
• 英文别名: methyl N-[(2S)-1-[(2S)-2-[5-[20-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]-8,17-dioxatetracyclo[16.4.0.02,7.010,15]docosa-1(18),2(7),3,5,10,12,14,19,21-nonaen-5-yl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate
• CAS: 1449762-38-2
• 化学式: C₄₈H₅₆N₈O₈
• 分子量: 873.021
• InChiKey: JGLSJPMJMQPTOX-MXAOVZPPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  64
• 可旋转键数：
  12
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  193
• 氢给体数：
  4
• 氢受体数：
  10

文献信息

• [EN] ANTIVIRAL COMPOUNDS WITH A DIBENZOOXAHETEROCYCLE MOIETY<br/>[FR] COMPOSÉS ANTIVIRAUX AVEC UNE FRACTION DIBENZOOXAHÉTÉROCYCLE
  申请人：LUPIN LTD

  公开号：WO2013118097A1

  公开（公告）日：2013-08-15

  Disclosed are compounds of formula (I) for use as antiviral agents, particularly as anti-hepatitis virus C agents, wherein R -R 6 and q are as described herein. Also disclosed are pharmaceutical compositions and methods of treating or preventing viral infection in a host by the use of these compounds, either alone or in combination with other pharmaceutically active agents. Further disclosed are methods of preparing such compounds.(I).

  公开了用作抗病毒剂的化合物(I)的公式，特别是作为抗丙型肝炎病毒药剂，其中R-R6和q如本文所述。还公开了利用这些化合物治疗或预防宿主病毒感染的药物组合和方法，无论是单独使用还是与其他药理活性剂结合使用。还公开了制备这种化合物的方法。(I)。
• Antiviral Compounds with a Dibenzooxaheterocycle Moiety
  申请人：Lupin Limited

  公开号：US20150010505A1

  公开（公告）日：2015-01-08

  Disclosed are compounds of formula (I) for use as antiviral agents, particularly as anti-hepatitis virus C agents, wherein R-R 6 and q are as described herein. Also disclosed are pharmaceutical compositions and methods of treating or preventing viral infection in a host by the use of these compounds, either alone or in combination with other pharmaceutically active agents. Further disclosed are methods of preparing such compounds. (I).

  本发明涉及一种式（I）的化合物，用作抗病毒剂，特别是抗丙型肝炎病毒的药物，其中R-R6和q如本文所述。本发明还涉及药物组合物和使用这些化合物单独或与其他药物活性剂联合治疗或预防宿主病毒感染的方法。本发明还涉及制备这些化合物的方法。(I)。
• US9073943B2
  申请人：——

  公开号：US9073943B2

  公开（公告）日：2015-07-07