10-(4-(2-(pyrrolidin-1-yl)-ethyl)-piperazin-1-ylmethyl)-2H-7-oxa-1,2-diazabenzo[de]anthracen-3-one | 902128-84-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 10-(4-(2-(pyrrolidin-1-yl)-ethyl)-piperazin-1-ylmethyl)-2H-7-oxa-1,2-diazabenzo[de]anthracen-3-one
• 英文别名: 4-[[4-(2-Pyrrolidin-1-ylethyl)piperazin-1-yl]methyl]-8-oxa-15,16-diazatetracyclo[7.7.1.02,7.013,17]heptadeca-1(16),2(7),3,5,9,11,13(17)-heptaen-14-one
• CAS: 902128-84-1
• 化学式: C₂₅H₂₉N₅O₂
• 分子量: 431.538
• InChiKey: FHYSCXDWGBCHGU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  60.4
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Diazabenzo[de]anthracen-3-one compounds and methods for inhibiting PARP
  申请人：Eisai Inc.

  公开号：EP2319847A2

  公开（公告）日：2011-05-11

  The present invention relates to diazabenzo[de]anthracen-3-one compounds which inhibit poly(ADP-ribose) polymerase ('PARP'), compositions containing these compounds and methods for using these PARP inhibitors to treat, prevent and/or ameliorate the effects of the conditions described herein.

  本发明涉及抑制聚（ADP-核糖）聚合酶（'PARP'）的重氮苯并[de]蒽-3-酮化合物、含有这些化合物的组合物以及使用这些 PARP 抑制剂治疗、预防和/或改善本文所述病症影响的方法。
• Diazabenzo[De]anthracen-3-one Compounds and Methods for Inhibiting Parp
  申请人：Xu Weizheng

  公开号：US20090028815A1

  公开（公告）日：2009-01-29

  The present invention relates to diazabenzo[de]anthracen-3-one compounds which inhibit poly(ADP-ribose) polymerase (“PARP”), compositions containing these compounds and methods for using these PARP inhibitors to treat, prevent and/or ameliorate the effects of the conditions described herein.
• DIAZABENZO[DE] ANTHRACEN-3-ONE COMPOUNDS AND METHODS FOR INHIBITING PARP
  申请人：Xu Weizheng

  公开号：US20110092478A1

  公开（公告）日：2011-04-21

  The present invention relates to diazabenzo[de]anthracen-3-one compounds which inhibit poly(ADP-ribose) polymerase (“PARP”), compositions containing these compounds and methods for using these PARP inhibitors to treat, prevent and/or ameliorate the effects of the conditions described herein.
• US7820668B2
  申请人：——

  公开号：US7820668B2

  公开（公告）日：2010-10-26
• US8058275B2
  申请人：——

  公开号：US8058275B2

  公开（公告）日：2011-11-15