(E)-3-Phenyl-pent-2-enethioic acid diphenylamide | 176715-86-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (E)-3-Phenyl-pent-2-enethioic acid diphenylamide
• CAS: 176715-86-9
• 化学式: C₂₃H₂₁NS
• 分子量: 343.492
• InChiKey: WTKZVIXQCDLNKN-VHEBQXMUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.65
• 重原子数：
  25.0
• 可旋转键数：
  5.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  3.24
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  (E)-3-Phenyl-pent-2-enethioic acid diphenylamide 以 solid 为溶剂， 反应 24.0h， 生成 (Z)-N,N,3-triphenylpent-2-enethioamide
  参考文献：
  名称：

  固态α,β-不饱和酰胺和硫代酰胺的光化学EZ-异构化

  摘要：

  α,β-不饱和酰胺在固态时的异构化能力较低，通过对其结构进行修饰，其固态EZ异构化能力得到了极大的提高；EZ-异构化是通过用硫代羰基取代酰胺的羰基以及用同手性取代酰胺的杂手性N-取代基来实现的。晶体学分析表明，固态的 α,β-不饱和酰胺和硫代酰胺的异构化部分取决于它们在晶体中的分子构象。此外，发现填充系数与异构化能力相关；较小的填充系数值会导致 (Z)-异构体的形成增加。

  DOI：

  10.1246/bcsj.69.779
• 作为产物：
  描述：

  (E)-3-Phenyl-pent-2-enoic acid diphenylamide 在 劳森试剂 作用下， 以 甲苯 为溶剂， 反应 1.0h， 生成 (E)-3-Phenyl-pent-2-enethioic acid diphenylamide
  参考文献：
  名称：

  固态α,β-不饱和酰胺和硫代酰胺的光化学EZ-异构化

  摘要：

  α,β-不饱和酰胺在固态时的异构化能力较低，通过对其结构进行修饰，其固态EZ异构化能力得到了极大的提高；EZ-异构化是通过用硫代羰基取代酰胺的羰基以及用同手性取代酰胺的杂手性N-取代基来实现的。晶体学分析表明，固态的 α,β-不饱和酰胺和硫代酰胺的异构化部分取决于它们在晶体中的分子构象。此外，发现填充系数与异构化能力相关；较小的填充系数值会导致 (Z)-异构体的形成增加。

  DOI：

  10.1246/bcsj.69.779

文献信息

• EZ-Isomerization of α,β-punsaturated Acid Derivatives in the Solid State
  作者：Kazushi Kinbara、Akiyoshi Kai、Yasunari Maekawa、Yukihiko Hashimoto、Shoji Naruse、Masaki Hasegawa、Kazuhiko Saigo

  DOI：10.1080/10587259608039371

  日期：1996.2

  The solid-state EZ-isomerizability of alpha,beta-unsaturated amide was greatly improved by modifying their structure, which had low isomerizability in the solid state; EZ-isomerizability was attained by replacing the carbonyl group of the amides by a thiocarbonyl group as well as replacing the heterochiral N-substituent of the amides by a homochiral one. Furthermore, EZ-photoisomerization was also attained for several kinds of salts of alpha,beta-unsaturated carboxylic acids with amines. This photoreaction was proven to be an effective method for preparing (Z)-isomers from ammonium (E)-alpha,beta-unsaturated carboxylates. The isomerizability was strikingly altered upon changing the ammonium part, which implied that the crystal structure affected the reactivity to a considerable extent. A further detailed study concerning the crystal structures suggested that the characteristic of the hydrogen-bond network had a close correlation with the isomerizability. Moreover, both the bulkiness of the carboxylate and ammonium parts as well as their difference in length were considered to be the most important factors influencing the isomerizability.