N-((2-hydroxynaphthalen-1-yl)(3-hydroxyphenyl)methyl)acetamide | 1372711-82-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-((2-hydroxynaphthalen-1-yl)(3-hydroxyphenyl)methyl)acetamide
• 英文别名: N-[(3-hydroxyphenyl)(2-hydroxynaphthalen-1-yl)methyl]acetamide；N-[(3-hydroxy-phenyl)-(2-hydroxy-naphthalen-1-yl)-methyl]-acetamide；N-[(2-hydroxynaphthalen-1-yl)-(3-hydroxyphenyl)methyl]acetamide
• CAS: 1372711-82-4
• 化学式: C₁₉H₁₇NO₃
• 分子量: 307.349
• InChiKey: QQJKEHGWTQABRE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  69.6
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  乙酰胺 、 间羟基苯甲醛 、 2-萘酚 在 Homopiperazine sulfamic acid functionalized mesoporous silica nanoparticles 作用下， 以 neat (no solvent) 为溶剂， 反应 1.75h， 以90%的产率得到N-((2-hydroxynaphthalen-1-yl)(3-hydroxyphenyl)methyl)acetamide
  参考文献：
  名称：

  均哌嗪氨基磺酸官能化的介孔二氧化硅纳米粒子（MSNs-HPZ-SO 3 H）作为一锅合成1-酰胺基-2-萘的有效催化剂

  摘要：

  介孔二氧化硅纳米粒子被高哌嗪氨基磺酸有效地官能化。所得的MSNs-HPZ-SO 3 H在热溶剂-下，通过芳族醛，酰胺/脲和β-萘酚的三组分缩合反应，被用作一锅合成1-酰胺烷基-2-萘的纳米催化剂。免费条件。催化剂的表征使用XRD，SEM，FT-IR，TGA-DTA和氮吸附-解吸分析进行。该方案被开发为一种利用生态友好型催化剂合成1-氨基烷基-2-萘酚的安全便捷的替代方法。

  DOI：

  10.1039/c5nj02974k

文献信息

• Tetrakis(acetonitrile)copper(I) Hexafluorophosphate–Promoted Efficient Synthesis of Amidoalkyl Naphthols Under Solvent-Free Conditions
  作者：Ebrahim Soleimani、Mohsen Zainali

  DOI：10.1080/00397911.2010.545497

  日期：2012.7.1

  preparation of amidoalkyl naphthols employing a multicomponent, one-pot condensation reaction of β-naphthol, aromatic aldehydes, and amides (acetamide, benzamide, and urea) in the presence of tetrakis(acetonitrile)copper(I) hexafluorophosphate [Cu(CH3CN)4PF6] under solvent-free conditions at 80 °C is described. Good yields, short reaction time, and easy workup are advantages of this procedure. GRAPHICAL

  摘要 在四（乙腈）铜 (I) 存在下，使用 β-萘酚、芳香醛和酰胺（乙酰胺、苯甲酰胺和尿素）的多组分、一锅缩合反应制备酰氨基烷基萘酚的有效和直接方案。 ) 六氟磷酸盐 [Cu(CH3CN)4PF6] 在 80 °C 下的无溶剂条件下进行了描述。该方法的优点是收率高、反应时间短且易于处理。图形概要
• Magnetic phosphonium ionic liquid: Application as a novel dual role acidic catalyst for synthesis of 2′-aminobenzothiazolomethylnaphthols and amidoalkyl naphthols
  作者：Morteza Torabi、Meysam Yarie、Mohammad Ali Zolfigol、Saeid Azizian

  DOI：10.1007/s11164-019-03996-w

  日期：2020.1

  Abstract In this investigation, a novel magnetic phosphonium ionic liquid (MPIL) was designed and synthesized through a two-step process. The resulting magnetic ionic liquid was fully characterized using different techniques including Fourier-transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), derivative thermogravimetric analysis (DTG), energy-dispersive X-ray spectroscopy (EDX)

  摘要 在这项研究中，设计并通过两步过程合成了一种新型的磁性and离子液体（MPIL）。使用包括傅里叶变换红外光谱（FT-IR），热重分析（TGA），微分热重分析（DTG），能量色散X射线光谱（EDX）和振动样品磁力计在内的各种技术对所得的磁性离子液体进行了全面表征（VSM）。制备的双酸性MPIL在合成2'-氨基苯并噻唑并甲基萘酚和酰胺基烷基萘酚衍生物方面具有出色的催化性能。单一化合物中磁性，布朗斯台德和路易斯酸能力的结合是制备MPIL的主要优势。目前的工作可以在合理设计的过程中开辟新的前景。 图形摘要 一种新型的磁性phospho离子液体促进了2'-氨基苯并噻唑并甲基萘酚和酰胺基烷基萘酚衍生物的合成。
• MCM-41-N-propylsulfamic acid: An efficient catalyst for one-pot synthesis of 1-amidoalkyl-2-naphtols
  作者：Maryam Hajjami、Farshid Ghorbani、Fariba Bakhti

  DOI：10.1016/j.apcata.2013.11.002

  日期：2014.1

  An efficient, one-pot three-component condensation of aromatic aldehydes, acetamide and 2-naphtol in the presence of catalytic amounts of MCM-41-N-propylsulfamic acid under thermal solvent-free conditions is described for the preparation of 1-amidoalkyl-2-naphtols in good to excellent yields. In this work, MCM-41-N-propylsulfamic acid was prepared by reaction of propylamine functionalized MCM-41 and chlorosulfonic acid and characterized by FTIR, XRD and TGA. (C) 2013 Elsevier B.V. All rights reserved.
• Incredible Role of Glycerol in Multicomponent Synthesis of 2,3-Dihydroquinazoline-4(1H)-ones and 1-Amidoalkyl-2-naphthols
  作者：Maryam Hajjami、Fariba Bakhti、Elahe Ghiasbeygi

  DOI：10.5562/cca2637

  日期：——

  An efficient and green synthesis of 1-amidoalkyl-2-naphthols via one-pot three-component condensation of aromatic aldehydes, acetamide and 2-naphthol in the presence of catalytic amounts of glycerosulfonic acid in glycerol as a green solvent was elaborated. Also a simple method for the one-pot three-component synthesis of 2,3-dihydroquinazoline-4(1H)-ones using of isatoic anhydride, aldehydes and ammonium acetate in the presence of glycerol as a green catalyst and solvent was described. In this light we introduced the brilliant and valuable role of glycerol in the synthesis of 2,3-dihydroquinazoline-4(1H)ones and 1-amidoalkyl-2-naphthols.