1-(4-Chlorophenyl)-3-[(3-hydroxynaphthalene-2-carbonyl)amino]thiourea | 224456-17-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-(4-Chlorophenyl)-3-[(3-hydroxynaphthalene-2-carbonyl)amino]thiourea
• CAS: 224456-17-1
• 化学式: C₁₈H₁₄ClN₃O₂S
• 分子量: 371.847
• InChiKey: KESDFNINCLCRJV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  106
• 氢给体数：
  4
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(4-Chlorophenyl)-3-[(3-hydroxynaphthalene-2-carbonyl)amino]thiourea 在 sodium hydroxide 作用下， 以 水 为溶剂， 反应 2.0h， 以93%的产率得到1H-4,5-dihydro-3-(3-hydroxy-2-naphthyl)-4-(4-chlorophenyl)-1,2,4-triazoline-5-thione
  参考文献：
  名称：

  Dogan, H. Nese; Duran, Arzu; Rollas, Sevim, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2005, vol. 44, # 11, p. 2301 - 2307

  摘要：

  DOI：
• 作为产物：
  描述：

  3-羟基-2-萘酸肼 、 4-氯异硫氰酸苯酯 以 乙醇 为溶剂， 反应 3.0h， 生成 1-(4-Chlorophenyl)-3-[(3-hydroxynaphthalene-2-carbonyl)amino]thiourea
  参考文献：
  名称：

  Synthesis of new 2,5-Disubstituted-1,3,4-thiadiazoles and preliminary evaluation of anticonvulsant and antimicrobial activities

  摘要：

  Two new series of 2.5-disubstituted-1,3.4-thiadiazoles were synthesized for their possible anticonvulsant. antibacterial and antifungal activities. The degree of protection afforded by these compounds at a dose of 100 mg/kg ip against pentylene-tetrazole-induced convulsions in mice ranged from 0 to 90%, Among these compounds, 2a (90%) and 2g (70%) showed maximum protection. Antimicrobial tests showed that the MIC value of 3j against Pseudomanas aeruginosa was equal to that of penicillin. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(02)00143-8

文献信息

• Synthesis of new 2,5-Disubstituted-1,3,4-thiadiazoles and preliminary evaluation of anticonvulsant and antimicrobial activities
  作者：Hatice N Dogan、Arzu Duran、Sevim Rollas、Göksel Sener、Meral K Uysal、Dumrul Gülen

  DOI：10.1016/s0968-0896(02)00143-8

  日期：2002.9

  Two new series of 2.5-disubstituted-1,3.4-thiadiazoles were synthesized for their possible anticonvulsant. antibacterial and antifungal activities. The degree of protection afforded by these compounds at a dose of 100 mg/kg ip against pentylene-tetrazole-induced convulsions in mice ranged from 0 to 90%, Among these compounds, 2a (90%) and 2g (70%) showed maximum protection. Antimicrobial tests showed that the MIC value of 3j against Pseudomanas aeruginosa was equal to that of penicillin. (C) 2002 Elsevier Science Ltd. All rights reserved.
• Dogan, H. Nese; Duran, Arzu; Rollas, Sevim, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2005, vol. 44, # 11, p. 2301 - 2307
  作者：Dogan, H. Nese、Duran, Arzu、Rollas, Sevim

  DOI：——

  日期：——