10-(1-methyl-piperidin-4-ylidene)-10H-chromeno[3,2-b]pyridine | 54629-77-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 10-(1-methyl-piperidin-4-ylidene)-10H-chromeno[3,2-b]pyridine
• 英文别名: 1-methyl-4-(10H-[1]benzopyrano[3,2-b]pyridin-10-ylidene)piperidine；10-(1-Methylpiperidin-4-ylidene)chromeno[3,2-b]pyridine
• CAS: 54629-77-5
• 化学式: C₁₈H₁₈N₂O
• 分子量: 278.354
• InChiKey: PBDHNIGUZYXBGL-UHFFFAOYSA-N

物化性质

• 沸点：
  432.4±45.0 °C(Predicted)
• 密度：
  1.206±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  21
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  25.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  10-(1-methyl-piperidin-4-ylidene)-10H-chromeno[3,2-b]pyridine 、 溴化氰 以 乙腈 、 苯 为溶剂， 生成 1-CYANO-4-(10H-[1]BENZOPYRANO[3,2-b]PYRIDIN-10-YLIDENE)PIPERIDINE
  参考文献：
  名称：

  Benzopyrido piperidine, piperidylidene and piperazine compounds,

  摘要：

  揭示了一种新型苯并吡啶二烯、吡啶基亚烯和哌嗪化合物，其广义化学式为##STR1##，用于治疗哮喘、过敏和炎症。还公开了含有这些化合物的新型药物组合物以及生产这些化合物的方法。

  公开号：

  US05104876A1
• 作为产物：
  描述：

  1-azaxanthone 在 PPA 作用下， 生成 10-(1-methyl-piperidin-4-ylidene)-10H-chromeno[3,2-b]pyridine
  参考文献：
  名称：

  Benzopyranopyridine derivatives. 1. Aminoalkyl derivatives of the azaxanthenes as bronchodilating agents

  摘要：

  The preparation of the four isomeric azaxanthones 3 and a number of their aromatic ring substituted derivatives is described. These ketones were converted into the title compounds which were examined for their biological properties. The most interesting compound in this series, the 1-methyl-4-piperidylidene derivative of 1-azaxanthene, shows the profile of an orally effective potent bronchodilating agent as well as a moderate antihistamine. Biological properties of this compound were compared to a number of antihistamines as well as known bronchodilating agents. Structure-activity relationships are also discussed.

  DOI：

  10.1021/jm00235a001

文献信息

• Benzopyrido piperidine, piperidylidene and piperazine compounds,
  申请人：Schering Corporation

  公开号：US05104876A1

  公开（公告）日：1992-04-14

  Novel benzopyrido piperidiene, piperidylidene and piperazine compounds of the generalized formula ##STR1## are disclosed as useful for the treatment of asthma, allergy and inflammation. Novel pharmaceutical compositions containing such compounds and processes for producing the compounds are also disclosed.

  揭示了一种新型苯并吡啶二烯、吡啶基亚烯和哌嗪化合物，其广义化学式为##STR1##，用于治疗哮喘、过敏和炎症。还公开了含有这些化合物的新型药物组合物以及生产这些化合物的方法。
• Benzopyrido piperidine, piperidylidene and piperazine compounds, compositions, methods of manufacture and methods of use
  申请人：SCHERING CORPORATION

  公开号：EP0341860A1

  公开（公告）日：1989-11-15

  Novel benzopyrido piperidine, piperidylidene and piperazine compounds of the generalized formula are disclosed as useful for the treatment of asthma, allergy and inflammation. Novel pharmaceutical compositions containing such compounds and processes for producing the compounds are also disclosed.

  通式为哌啶、亚哌啶和哌嗪的新型苯并吡啶化合物 公开了可用于治疗哮喘、过敏和炎症的新型苯并吡啶哌啶、亚哌啶和哌嗪化合物。此外，还公开了含有此类化合物的新型药物组合物以及生产此类化合物的工艺。
• VILLANI F. J.; MANN T. A.; WEFER E. A.; HANNON J.; LARCA L. L.; LANDON M.+, J. MED. CHEM. <JMCM-AR>, 1975, 18, NO 1, 1-8
  作者：VILLANI F. J.、 MANN T. A.、 WEFER E. A.、 HANNON J.、 LARCA L. L.、 LANDON M.+

  DOI：——

  日期：——
• NOVEL BENZOPYRIDO PIPERIDINE, PIPERIDYLIDENE AND PIPERAZINE COMPOUNDS, COMPOSITIONS, METHODS OF MANUFACTURE AND METHODS OF USE
  申请人：SCHERING CORPORATION

  公开号：EP0411048A1

  公开（公告）日：1991-02-06
• BIS-BENZO OR BENZOPYRIDO CYCLO HEPTA PIPERIDENE, PIPERIDYLIDENE AND PIPERAZINE COMPOUNDS AND COMPOSITIONS
  申请人：SCHERING CORPORATION

  公开号：EP0535152A1

  公开（公告）日：1993-04-07