Daunorubicin, benzoylhydrazone, monohydrochloride

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 蒽环类药物
• 英文名称: Daunorubicin, benzoylhydrazone, monohydrochloride
• 英文别名: N-[(E)-1-[(2S,4S)-4-(4-amino-5-hydroxy-6-methyloxan-2-yl)oxy-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-3,4-dihydro-1H-tetracen-2-yl]ethylideneamino]benzamide
• 化学式: C₃₄H₃₅N₃O₁₀
• 分子量: 645.7
• InChiKey: FBTUMDXHSRTGRV-KYIOHIHWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  47
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  210
• 氢给体数：
  6
• 氢受体数：
  12

文献信息

• US7790905B2
  申请人：——

  公开号：US7790905B2

  公开（公告）日：2010-09-07
• US7927613B2
  申请人：——

  公开号：US7927613B2

  公开（公告）日：2011-04-19
• [EN] COMBINATION OF CIMETIDINE AND CYSTEINE DERIVATIVES FOR TREATING CANCER<br/>[FR] COMBINAISON DE DERIVES DE CIMETIDINE ET DE CYSTEINE POUR TRAITER LE CANCER
  申请人：ASTION ONCOLOGY APS

  公开号：WO2003045359A2

  公开（公告）日：2003-06-05

  The present invention relates to new substances in the form of chemical complexes comprising cimetidine or a derivative thereof and a cysteine derivative and to compositions comprising said complexes or combination. The invention further relates to the therapeutic effect of such combinations in relation to treating cancer, cancer chemoprevention or the suppression of hypersensitivity and/or inflammatory reactions of a mammal.
• [EN] INHIBITING THE DELETERIOUS EFFECT OF ANTHRACYCLINES<br/>[FR] INHIBITION DE L'EFFET DÉLÉTÈRE DES ANTHRACYCLINES
  申请人：UNIV OREGON HEALTH & SCIENCE

  公开号：WO2011050319A2

  公开（公告）日：2011-04-28

  This application provides methods that can be used to inhibit or treat deleterious effects of anthracycline administration (such as cardiomyopathy), as well as compositions and kits that can be used for such methods. For example, such methods can include administration of an inhibitor of ZAK activity to prevent or treat cardiotoxic effects of anthracycline, for example in a subject having a cancer responsive to anthracycline.